DegronMD - Q6UWW8(CES3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M289I	TCGA-BF-A1Q0	SKCM	TCGA	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1944
p.M289I	DO47374	SKCM	ICGC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1944
p.C281Y	DO230311	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.5976
p.A276T	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2222
p.A276T	SIDM00260	Gastric Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2222
p.A276T	SIDM00160	Biliary Tract Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2222
p.A276T	SIDM00248	Gastric Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2222
p.A276T	MKN28	stomach	COSMIC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2222
p.A276T	TE-6	oesophagus	COSMIC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2222
p.P286L	SIDM00677	Colorectal Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2778
p.P286L	LS-513	large intestine	COSMIC	ACSSS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons