DegronMD - Q9H019(MTFR1L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T181I	TCGA-06-0188	GBM	TCGA	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.0833
p.T181I	DO12658	GBM	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.0833
p.E191D	TCGA-AA-A010	COAD	TCGA	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.5647
p.A209V	TCGA-AP-A1DK	UCEC	TCGA	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.0833
p.A209V	DO42033	UCEC	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.0833
p.S224L	TCGA-AX-A1CE	UCEC	TCGA	ACSSS	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.8778
p.S224L	DO42280	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.8778
p.S224L	SIDM00118	Colorectal Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.8778
p.S224L	HCC2998	large intestine	COSMIC	ACSSS	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.8778
p.S210G	TCGA-CG-5721	STAD	TCGA	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.0556
p.C213Y	TCGA-CV-A45P	HNSC	TCGA	ACSSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.C213Y	DO219026	HNSC	ICGC	ACSSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.E194K	TCGA-XF-AAMQ	BLCA	TCGA	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.591
p.E194K	DO51934	BLCA	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.591
p.A194V	DO8119	COAD	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.6936
p.A194V	DO233652	GACA	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.6936
p.T190A	DO227987	COCA	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.7139
p.C207F	DO229015	LICA	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.1389
p.A209S	DO229032	LICA	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.0833
p.D188Y	DO229054	LICA	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.2778
p.E194D	DO48691	LIRI	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.5647
p.R188H	DO41199	UCEC	ICGC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.2778
p.E194G	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.6087
p.E194G	ACH-000611	Lymphoma	CCLE	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.6087
p.E194G	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.6087
p.I189T	SIDM00217	Colorectal Carcinoma	GDSC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.3056
p.I189T	ACH-000999	Colon/Colorectal Cancer	CCLE	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.3056
p.I189T	SNU-1040	large intestine	COSMIC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.3056
p.L206I	SIDM00217	Colorectal Carcinoma	GDSC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.1667
p.L206I	ACH-000999	Colon/Colorectal Cancer	CCLE	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.1667
p.L206I	SNU-1040	large intestine	COSMIC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.1667
p.S212L	HCC2998	large intestine	COSMIC	ACSSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0833
p.L194I	SNU-1040	large intestine	COSMIC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation altering degron motif	0.7174
p.R188C	HCC2998	large intestine	COSMIC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.2778
p.E182G	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	TEETEVEVPEL	DEG_COP1_1	190:200	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTFR1L

UniProt ID: Q9H019

Entrez ID: 56181

Protein name: Mitochondrial fission regulator 1-like

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTFR1L in