DegronMD

Uniprot ID: Q9H019

Source protein: Mitochondrial fission regulator 1-like

Source gene: MTFR1L

Class: DEG_COP1_1

Location: 190:200

E3 ligase: COP1

DEGRON score: 0.9041

ASA_SCORE: 99.4455

COIL: 0.9654

CONS_SCORE: 0.7053

DSS_SCORE: 0.404

HELIX: 0.0142

FCONS_SCORE: 0.9724

RIG_SCORE: 0.8101

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T181I	TCGA-06-0188	GBM	TCGA	TEETEVEVPEL	DEG_COP1_1	0.0833
p.T181I	DO12658	GBM	ICGC	TEETEVEVPEL	DEG_COP1_1	0.0833
p.E191D	TCGA-AA-A010	COAD	TCGA	TEETEVEVPEL	DEG_COP1_1	0.5647
p.A209V	TCGA-AP-A1DK	UCEC	TCGA	TEETEVEVPEL	DEG_COP1_1	0.0833
p.A209V	DO42033	UCEC	ICGC	TEETEVEVPEL	DEG_COP1_1	0.0833
p.S210G	TCGA-CG-5721	STAD	TCGA	TEETEVEVPEL	DEG_COP1_1	0.0556
p.E194K	TCGA-XF-AAMQ	BLCA	TCGA	TEETEVEVPEL	DEG_COP1_1	0.591
p.E194K	DO51934	BLCA	ICGC	TEETEVEVPEL	DEG_COP1_1	0.591
p.A194V	DO8119	COAD	ICGC	TEETEVEVPEL	DEG_COP1_1	0.6936
p.A194V	DO233652	GACA	ICGC	TEETEVEVPEL	DEG_COP1_1	0.6936
p.T190A	DO227987	COCA	ICGC	TEETEVEVPEL	DEG_COP1_1	0.7139
p.C207F	DO229015	LICA	ICGC	TEETEVEVPEL	DEG_COP1_1	0.1389
p.A209S	DO229032	LICA	ICGC	TEETEVEVPEL	DEG_COP1_1	0.0833
p.D188Y	DO229054	LICA	ICGC	TEETEVEVPEL	DEG_COP1_1	0.2778
p.E194D	DO48691	LIRI	ICGC	TEETEVEVPEL	DEG_COP1_1	0.5647
p.R188H	DO41199	UCEC	ICGC	TEETEVEVPEL	DEG_COP1_1	0.2778
p.E194G	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	TEETEVEVPEL	DEG_COP1_1	0.6087
p.E194G	ACH-000611	Lymphoma	CCLE	TEETEVEVPEL	DEG_COP1_1	0.6087
p.E194G	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	TEETEVEVPEL	DEG_COP1_1	0.6087
p.I189T	SIDM00217	Colorectal Carcinoma	GDSC	TEETEVEVPEL	DEG_COP1_1	0.3056
p.I189T	ACH-000999	Colon/Colorectal Cancer	CCLE	TEETEVEVPEL	DEG_COP1_1	0.3056
p.I189T	SNU-1040	large_intestine	COSMIC	TEETEVEVPEL	DEG_COP1_1	0.3056
p.L206I	SIDM00217	Colorectal Carcinoma	GDSC	TEETEVEVPEL	DEG_COP1_1	0.1667
p.L206I	ACH-000999	Colon/Colorectal Cancer	CCLE	TEETEVEVPEL	DEG_COP1_1	0.1667
p.L206I	SNU-1040	large_intestine	COSMIC	TEETEVEVPEL	DEG_COP1_1	0.1667
p.L194I	SNU-1040	large_intestine	COSMIC	TEETEVEVPEL	DEG_COP1_1	0.7174
p.R188C	HCC2998	large_intestine	COSMIC	TEETEVEVPEL	DEG_COP1_1	0.2778
p.E182G	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	TEETEVEVPEL	DEG_COP1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TEETEVEVPEL

Degron related mutations and impact score

Drug responses associated with MTFR1L mutations

All proteins holding degron of TEETEVEVPEL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H019	Mitochondrial fission regulator 1-like	DEG_COP1_1	190:200	TEETEVEVPEL	COP1	0.9041	More...