DegronMD

Uniprot ID: O60870

Source protein: DNA/RNA-binding protein KIN17

Source gene: KIN

Class: DEG_COP1_1

Location: 182:191

E3 ligase: COP1

DEGRON score: 0.9575

ASA_SCORE: 81.96

COIL: 0.7304

CONS_SCORE: 0.3379

DSS_SCORE: 0.5526

HELIX: 0.1513

FCONS_SCORE: 0.7148

RIG_SCORE: 0.72

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E185K	TCGA-05-4417	LUAD	TCGA	EGKEQEVPTF	DEG_COP1_1	0.7022
p.E185K	DO23570	LUAD	ICGC	EGKEQEVPTF	DEG_COP1_1	0.7022
p.Q176H	TCGA-22-0940	LUSC	TCGA	EGKEQEVPTF	DEG_COP1_1	0.1667
p.Q176H	DO26794	LUSC	ICGC	EGKEQEVPTF	DEG_COP1_1	0.1667
p.P189S	TCGA-D3-A3C7	SKCM	TCGA	EGKEQEVPTF	DEG_COP1_1	0.6752
p.P189S	DO47569	SKCM	ICGC	EGKEQEVPTF	DEG_COP1_1	0.6752
p.E193K	DO230326	COCA	ICGC	EGKEQEVPTF	DEG_COP1_1	0.2778
p.E174K	DO233284	GACA	ICGC	EGKEQEVPTF	DEG_COP1_1	0.1111
p.Q186K	DO228971	LICA	ICGC	EGKEQEVPTF	DEG_COP1_1	0.5833
p.T190N	DO46368	OV	ICGC	EGKEQEVPTF	DEG_COP1_1	0.7055
p.I173L	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	EGKEQEVPTF	DEG_COP1_1	0.0833
p.I173L	ACH-000561	Esophageal Cancer	CCLE	EGKEQEVPTF	DEG_COP1_1	0.0833
p.I173L	T-T	oesophagus	COSMIC	EGKEQEVPTF	DEG_COP1_1	0.0833
p.N198S	SIDM00683	Prostate Carcinoma	GDSC	EGKEQEVPTF	DEG_COP1_1	0.1389
p.N198S	ACH-000977	lymph_node	CCLE	EGKEQEVPTF	DEG_COP1_1	0.1389
p.N198S	LNCaP-Clone-FGC	prostate	COSMIC	EGKEQEVPTF	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60870	DNA/RNA-binding protein KIN17	DEG_COP1_1	182:191	EGKEQEVPTF	COP1	0.9575	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons