DegronMD

Uniprot ID: Q86WB0

Source protein: Zinc finger C3HC-type protein 1

Source gene: ZC3HC1

Class: DEG_SCF_SKP2-CKS1_1

Location: 24:31

E3 ligase: SKP2,CSK1

DEGRON score: 0.9984

ASA_SCORE: 73.025

COIL: 0.6868

CONS_SCORE: 0.4426

DSS_SCORE: 0.4708

HELIX: 0.2996

FCONS_SCORE: 1.1509

RIG_SCORE: 0.7246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R23C	TCGA-DK-A1A3	BLCA	TCGA	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.3056
p.R23C	DO558	BLCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E38K	TCGA-FD-A5BX	BLCA	TCGA	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E38K	TCGA-K4-A54R	BLCA	TCGA	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E38K	DO44079	BLCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E38K	DO48611	BLCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S23Y	DO14171	HNSC	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.3056
p.T28N	DO229028	LICA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.8166
p.T28N	SIDM00940	Breast Carcinoma	GDSC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.8166
p.T28N	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.8166
p.H15Q	DO229034	LICA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A41V	DO232224	PBCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.Y21F	DO229272	THCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.P29S	SIDM00777	Colorectal Carcinoma	GDSC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P29S	NCI-H508	large_intestine	COSMIC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.6752
p.R25T	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.7876
p.R25T	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WB0	Zinc finger C3HC-type protein 1	DEG_SCF_SKP2-CKS1_1	24:31	SPEGTPQK	SKP2,CSK1	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons