DegronMD

Uniprot ID: P50548

Source protein: ETS domain-containing transcription factor ERF

Source gene: ERF

Class: DEG_ODPH_VHL_1

Location: 416:427

E3 ligase: VHL

DEGRON score: 0.8658

ASA_SCORE: 91.0167

COIL: 0.8892

CONS_SCORE: 0.3967

DSS_SCORE: 0.7565

HELIX: 0.016

FCONS_SCORE: 1.1091

RIG_SCORE: 0.5988

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P420L	TCGA-D5-6928	COAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6471
p.G414V	TCGA-IB-7651	PAAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.2778
p.A417V	TCGA-XK-AAIW	PRAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6936
p.E432K	DO51639	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944
p.D416N	DO49939	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6932
p.E430Q	DO48989	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.R412S	DO229029	LICA	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.2222
p.R412L	DO25189	LUAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.2222
p.R408H	DO46657	PAAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1111
p.R412C	DO37991	SKCM	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.2222
p.G433V	DO38495	STAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1667
p.R411W	DO38619	STAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944
p.R411W	DO38259	STAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944
p.R418H	DO43306	UCEC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.8244
p.R418H	DO43755	UCEC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.8244
p.A413T	SIDM00789	Colorectal Carcinoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	ACH-000509	Lymphoma	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	ACH-002240	Lymphoma	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	H9	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	HCT-15	large_intestine	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.S431L	SIDM00917	Acute Myeloid Leukemia	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6667
p.S431L	ACH-002218	Leukemia	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6667
p.S431L	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6667
p.E432D	SIDM00999	Bladder Carcinoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944
p.E432D	ACH-000973	Bladder Cancer	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944
p.E432D	639-V	urinary_tract	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPPPPPPQIKV

Degron related mutations and impact score

Drug responses associated with ERF mutations

All proteins holding degron of LAPPPPPPQIKV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50548	ETS domain-containing transcription factor ERF	DEG_ODPH_VHL_1	416:427	LAPPPPPPQIKV	VHL	0.8658	More...