DegronMD

Uniprot ID: P50548

Source protein: ETS domain-containing transcription factor ERF

Source gene: ERF

Class: DEG_ODPH_VHL_1

Location: 416:427

E3 ligase: VHL

DEGRON score: 0.8658

ASA_SCORE: 91.0167

COIL: 0.8892

CONS_SCORE: 0.3967

DSS_SCORE: 0.7565

HELIX: 0.016

FCONS_SCORE: 1.1091

RIG_SCORE: 0.5988

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R418H	DO43306	UCEC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.8244
p.R418H	DO43755	UCEC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.8244
p.A417V	TCGA-XK-AAIW	PRAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6936
p.D416N	DO49939	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6932
p.S431L	SIDM00917	Acute Myeloid Leukemia	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6667
p.S431L	ACH-002218	Leukemia	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6667
p.S431L	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6667
p.P420L	TCGA-D5-6928	COAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.6471
p.G414V	TCGA-IB-7651	PAAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.2778
p.E430Q	DO48989	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	SIDM00789	Colorectal Carcinoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	ACH-000509	Lymphoma	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	ACH-002240	Lymphoma	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	H9	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.A413T	HCT-15	large_intestine	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.25
p.R412S	DO229029	LICA	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.2222
p.R412L	DO25189	LUAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.2222
p.R412C	DO37991	SKCM	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.2222
p.E432K	DO51639	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944
p.R411W	DO38619	STAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944
p.R411W	DO38259	STAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944
p.E432D	SIDM00999	Bladder Carcinoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	0.1944

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Drug responses associated with ERF mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LAPPPPPPQIKV

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50548	ETS domain-containing transcription factor ERF	DEG_ODPH_VHL_1	416:427	LAPPPPPPQIKV	VHL	0.8658	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPPPPPPQIKV

Degron related mutations and impact score

Drug responses associated with ERF mutations

All proteins holding degron of LAPPPPPPQIKV