DegronMD - Q02388(COL7A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V689L	TCGA-12-0827	GBM	TCGA	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1111
p.V689L	DO12538	GBM	ICGC	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1111
p.A1195V	TCGA-2H-A9GO	ESCA	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation rewiring degron network	0.1111
p.S1823Y	TCGA-46-3765	LUSC	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation rewiring degron network	0.0833
p.S1823Y	DO26959	LUSC	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation rewiring degron network	0.0833
p.N1796T	TCGA-49-AARN	LUAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation rewiring degron network	0.0556
p.N1796T	DO218923	LUAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation rewiring degron network	0.0556
p.L1813F	TCGA-49-AARO	LUAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.6981
p.L1813F	DO218924	LUAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.6981
p.V461E	TCGA-55-7913	LUAD	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.1667
p.V461E	DO223665	LUAD	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.1667
p.D1208N	TCGA-A5-A0G2	UCEC	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.5821
p.D1208N	DO41235	UCEC	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.5821
p.V702I	TCGA-AA-3877	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.3056
p.V702I	DO7855	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.3056
p.A1204V	TCGA-AA-A00Z	COAD	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6936
p.A1204V	DO227892	BRCA	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6936
p.A1204V	DO9066	COAD	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6936
p.P457Q	TCGA-AP-A059	UCEC	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.0556
p.P457Q	DO41361	UCEC	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.0556
p.P476L	TCGA-AX-A05T	UCEC	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.3056
p.P476L	DO42649	UCEC	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.3056
p.P476L	SIDM00319	Melanoma	GDSC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.3056
p.P476L	ACH-001704	Skin Cancer	CCLE	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.3056
p.P476L	VMRC-MELG	skin	COSMIC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.3056
p.G1812C	TCGA-AX-A06F	UCEC	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.6489
p.G1812C	DO41752	UCEC	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.6489
p.A1215T	TCGA-AX-A1C9	UCEC	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6028
p.A1215T	DO43098	UCEC	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6028
p.V1216M	TCGA-B5-A1MX	UCEC	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6097
p.V1216M	TCGA-KC-A7FD	PRAD	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6097
p.V1216M	DO233652	GACA	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6097
p.V1216M	DO219291	PRAD	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6097
p.V1216M	DO41999	UCEC	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6097
p.G1821D	TCGA-BR-6452	STAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation rewiring degron network	0.1389
p.G1821D	DO38404	STAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation rewiring degron network	0.1389
p.G1821D	DO42673	UCEC	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation rewiring degron network	0.1389
p.R1201H	TCGA-CK-5914	COAD	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation rewiring degron network	0.2778
p.R1201H	DO9658	COAD	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation rewiring degron network	0.2778
p.R1814H	TCGA-CM-6162	COAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.7133
p.R1814H	TCGA-VQ-A8PO	STAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.7133
p.R1814H	DO8479	COAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.7133
p.R1814H	DO51773	STAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.7133
p.R1814H	SIDM00577	Neuroblastoma	GDSC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.7133
p.R1814H	ACH-001603	Neuroblastoma	CCLE	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.7133
p.R1814H	NH-12	autonomic ganglia	COSMIC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.7133
p.R1807I	TCGA-E6-A1LX	UCEC	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.8102
p.R1807I	DO41020	UCEC	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.8102
p.M1207I	TCGA-EE-A2GH	SKCM	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6507
p.M1207I	DO37643	SKCM	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6507
p.M1207I	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6507
p.M1207I	ACH-000157	Lymphoma	CCLE	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6507
p.M1207I	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6507
p.R1814C	TCGA-EE-A2GO	SKCM	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.719
p.R1814C	DO37823	SKCM	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.719
p.V692I	TCGA-EE-A2MS	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1944
p.V692I	DO37567	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1944
p.P463L	TCGA-EE-A3AB	SKCM	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.2222
p.P463L	DO222670	MELA	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.2222
p.P463L	DO38057	SKCM	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.2222
p.V1216G	TCGA-FI-A2D5	UCEC	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.7532
p.V1216G	DO41331	UCEC	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.7532
p.D970N	TCGA-FI-A2D5	UCEC	TCGA	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.0556
p.D970N	DO41331	UCEC	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.0556
p.T703I	TCGA-FS-A1Z3	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation blocking phosphorylation signal	0.7222
p.T703I	DO37635	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation blocking phosphorylation signal	0.7222
p.R481C	TCGA-GN-A266	SKCM	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.1667
p.R481C	DO37432	SKCM	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.1667
p.R963C	TCGA-GV-A6ZA	BLCA	TCGA	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.25
p.R963C	DO49776	BLCA	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.25
p.R963C	SIDM00217	Colorectal Carcinoma	GDSC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.25
p.R963C	ACH-000999	Colon/Colorectal Cancer	CCLE	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.25
p.R963C	SNU-1040	large intestine	COSMIC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.25
p.S959R	TCGA-LN-A5U7	ESCA	TCGA	TESPRVPSI	DEG_COP1_1	952:960	Mutation altering degron motif	0.7427
p.R1814L	DO48388	BLCA	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.7316
p.R481H	DO227745	COCA	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.1667
p.R951H	DO222501	COCA	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.3056
p.R951C	DO234393	ESAD	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.3056
p.R951C	DO233261	GACA	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.3056
p.A1799S	DO233265	GACA	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation rewiring degron network	0.1389
p.T967N	DO228974	LICA	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.1389
p.P944T	DO229018	LICA	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.1111
p.R951S	DO229029	LICA	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.3056
p.R963S	DO229028	LICA	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.25
p.E953K	DO229275	THCA	ICGC	TESPRVPSI	DEG_COP1_1	952:960	Mutation altering degron motif	0.591
p.L1813I	SIDM01278	Colorectal Carcinoma	GDSC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.6063
p.G711D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.G711D	ACH-000995	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.G711D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.S464F	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.25
p.S464F	ACH-000840	Lung Cancer	CCLE	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.25
p.S464F	HCC-366	lung	COSMIC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.25
p.A946T	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.1667
p.A946T	ACH-000587	Lung Cancer	CCLE	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.1667
p.A946T	NCI-H1975	lung	COSMIC	TESPRVPSI	DEG_COP1_1	952:960	Mutation rewiring degron network	0.1667
p.P958S	SIDM00781	Colorectal Carcinoma	GDSC	TESPRVPSI	DEG_COP1_1	952:960	Mutation altering degron motif	0.6752
p.P958S	SIDM00780	Colorectal Carcinoma	GDSC	TESPRVPSI	DEG_COP1_1	952:960	Mutation altering degron motif	0.6752
p.P958S	ACH-000967	Colon/Colorectal Cancer	CCLE	TESPRVPSI	DEG_COP1_1	952:960	Mutation altering degron motif	0.6752
p.P958S	ACH-001199	Colon/Colorectal Cancer	CCLE	TESPRVPSI	DEG_COP1_1	952:960	Mutation altering degron motif	0.6752
p.P958S	SNU-C2B	large intestine	COSMIC	TESPRVPSI	DEG_COP1_1	952:960	Mutation altering degron motif	0.6752
p.T1212A	SIDM00945	Colorectal Carcinoma	GDSC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6028
p.T1212A	ACH-000895	Colon/Colorectal Cancer	CCLE	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6028
p.T1212A	CL-34	large intestine	COSMIC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation altering degron motif	0.6028
p.T691M	SIDM00193	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation blocking phosphorylation signal	0.6111
p.T691M	SNU-81	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation blocking phosphorylation signal	0.6111
p.P457L	SIDM00476	Ovarian Carcinoma	GDSC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.0556
p.P457L	OV-17R	ovary	COSMIC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.0556
p.R468C	SIDM00140	Melanoma	GDSC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation altering degron motif	0.8301
p.R468C	ACH-000968	Skin Cancer	CCLE	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation altering degron motif	0.8301
p.R468C	COLO-792	skin	COSMIC	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation altering degron motif	0.8301
p.A1193D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation rewiring degron network	0.0556
p.A1193D	ACH-001127	Leukemia	CCLE	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation rewiring degron network	0.0556
p.A1193D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation rewiring degron network	0.0556
p.P1811L	SIDM00980	Gastric Carcinoma	GDSC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.6471
p.P1811L	ACH-000948	Gastric Cancer	CCLE	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.6471
p.P1811L	23132-87	stomach	COSMIC	GRDGLPGLR	DEG_APCC_DBOX_1	1806:1814	Mutation altering degron motif	0.6471
p.R1202C	SIDM01451	Pancreatic Carcinoma	GDSC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation rewiring degron network	0.3056
p.R1202C	ACH-000933	Pancreatic Cancer	CCLE	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	1203:1216	Mutation rewiring degron network	0.3056
p.D465G	ACH-000887	Brain Cancer	CCLE	TRYQLDGLQ	DEG_APCC_DBOX_1	467:475	Mutation rewiring degron network	0.2778
p.A697T	ACH-000979	Prostate Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	697:701	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL7A1

UniProt ID: Q02388

Entrez ID: 1294

Protein name: Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL7A1 in