DegronMD

Uniprot ID: Q02388

Source protein: Collagen alpha-1

Source gene: COL7A1

Class: DEG_ODPH_VHL_1

Location: 1203:1216

E3 ligase: VHL

DEGRON score: 0.9237

ASA_SCORE: 49.8571

COIL: 0.7259

CONS_SCORE: 0.3918

DSS_SCORE: 0.3504

HELIX: 0.0796

FCONS_SCORE: 0.9233

RIG_SCORE: 0.7786

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1195V	TCGA-2H-A9GO	ESCA	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.1111
p.D1208N	TCGA-A5-A0G2	UCEC	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.5821
p.D1208N	DO41235	UCEC	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.5821
p.A1204V	TCGA-AA-A00Z	COAD	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6936
p.A1204V	DO227892	BRCA	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6936
p.A1204V	DO9066	COAD	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6936
p.A1215T	TCGA-AX-A1C9	UCEC	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6028
p.A1215T	DO43098	UCEC	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6028
p.V1216M	TCGA-B5-A1MX	UCEC	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6097
p.V1216M	TCGA-KC-A7FD	PRAD	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6097
p.V1216M	DO233652	GACA	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6097
p.V1216M	DO219291	PRAD	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6097
p.V1216M	DO41999	UCEC	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6097
p.R1201H	TCGA-CK-5914	COAD	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.2778
p.R1201H	DO9658	COAD	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.2778
p.M1207I	TCGA-EE-A2GH	SKCM	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6507
p.M1207I	DO37643	SKCM	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6507
p.M1207I	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6507
p.M1207I	ACH-000157	Lymphoma	CCLE	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6507
p.M1207I	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6507
p.V1216G	TCGA-FI-A2D5	UCEC	TCGA	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.7532
p.V1216G	DO41331	UCEC	ICGC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.7532
p.T1212A	SIDM00945	Colorectal Carcinoma	GDSC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6028
p.T1212A	ACH-000895	Colon/Colorectal Cancer	CCLE	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6028
p.T1212A	CL-34	large_intestine	COSMIC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.6028
p.A1193D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.0556
p.A1193D	ACH-001127	Leukemia	CCLE	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.0556
p.A1193D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.0556
p.R1202C	SIDM01451	Pancreatic Carcinoma	GDSC	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.3056
p.R1202C	ACH-000933	Pancreatic Cancer	CCLE	LAPGMDSVQTFFAV	DEG_ODPH_VHL_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGMDSVQTFFAV

Degron related mutations and impact score

Drug responses associated with COL7A1 mutations

All proteins holding degron of LAPGMDSVQTFFAV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02388	Collagen alpha-1	DEG_ODPH_VHL_1	1203:1216	LAPGMDSVQTFFAV	VHL	0.9237	More...