DegronMD

Uniprot ID: Q02388

Source protein: Collagen alpha-1

Source gene: COL7A1

Class: DEG_APCC_DBOX_1

Location: 1806:1814

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9647

ASA_SCORE: 78.5

COIL: 0.9181

CONS_SCORE: 0.5235

DSS_SCORE: 0.8413

HELIX: 0.0147

FCONS_SCORE: 0.9936

RIG_SCORE: 0.5784

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1823Y	TCGA-46-3765	LUSC	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.0833
p.S1823Y	DO26959	LUSC	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.0833
p.N1796T	TCGA-49-AARN	LUAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.0556
p.N1796T	DO218923	LUAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.0556
p.L1813F	TCGA-49-AARO	LUAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.6981
p.L1813F	DO218924	LUAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.6981
p.G1812C	TCGA-AX-A06F	UCEC	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.6489
p.G1812C	DO41752	UCEC	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.6489
p.G1821D	TCGA-BR-6452	STAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.1389
p.G1821D	DO38404	STAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.1389
p.G1821D	DO42673	UCEC	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.1389
p.R1814H	TCGA-CM-6162	COAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.7133
p.R1814H	TCGA-VQ-A8PO	STAD	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.7133
p.R1814H	DO8479	COAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.7133
p.R1814H	DO51773	STAD	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.7133
p.R1814H	SIDM00577	Neuroblastoma	GDSC	GRDGLPGLR	DEG_APCC_DBOX_1	0.7133
p.R1814H	ACH-001603	Neuroblastoma	CCLE	GRDGLPGLR	DEG_APCC_DBOX_1	0.7133
p.R1814H	NH-12	autonomic_ganglia	COSMIC	GRDGLPGLR	DEG_APCC_DBOX_1	0.7133
p.R1807I	TCGA-E6-A1LX	UCEC	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.8102
p.R1807I	DO41020	UCEC	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.8102
p.R1814C	TCGA-EE-A2GO	SKCM	TCGA	GRDGLPGLR	DEG_APCC_DBOX_1	0.719
p.R1814C	DO37823	SKCM	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.719
p.R1814L	DO48388	BLCA	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.7316
p.A1799S	DO233265	GACA	ICGC	GRDGLPGLR	DEG_APCC_DBOX_1	0.1389
p.L1813I	SIDM01278	Colorectal Carcinoma	GDSC	GRDGLPGLR	DEG_APCC_DBOX_1	0.6063
p.P1811L	SIDM00980	Gastric Carcinoma	GDSC	GRDGLPGLR	DEG_APCC_DBOX_1	0.6471
p.P1811L	ACH-000948	Gastric Cancer	CCLE	GRDGLPGLR	DEG_APCC_DBOX_1	0.6471
p.P1811L	23132-87	stomach	COSMIC	GRDGLPGLR	DEG_APCC_DBOX_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRDGLPGLR

Degron related mutations and impact score

Drug responses associated with COL7A1 mutations

All proteins holding degron of GRDGLPGLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02388	Collagen alpha-1	DEG_APCC_DBOX_1	1806:1814	GRDGLPGLR	APC,CDC20,FZR1	0.9647	More...