DegronMD

Uniprot ID: Q02388

Source protein: Collagen alpha-1

Source gene: COL7A1

Class: DEG_APCC_DBOX_1

Location: 467:475

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6749

ASA_SCORE: 62.6556

COIL: 0.4738

CONS_SCORE: 0.531

DSS_SCORE: 0.3574

HELIX: 0.0213

FCONS_SCORE: 1.0342

RIG_SCORE: 0.7925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V461E	TCGA-55-7913	LUAD	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	0.1667
p.V461E	DO223665	LUAD	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.1667
p.P457Q	TCGA-AP-A059	UCEC	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	0.0556
p.P457Q	DO41361	UCEC	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.0556
p.P476L	TCGA-AX-A05T	UCEC	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	0.3056
p.P476L	DO42649	UCEC	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.3056
p.P476L	SIDM00319	Melanoma	GDSC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.3056
p.P476L	ACH-001704	Skin Cancer	CCLE	TRYQLDGLQ	DEG_APCC_DBOX_1	0.3056
p.P476L	VMRC-MELG	skin	COSMIC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.3056
p.P463L	TCGA-EE-A3AB	SKCM	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	0.2222
p.P463L	DO222670	MELA	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.2222
p.P463L	DO38057	SKCM	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.2222
p.R481C	TCGA-GN-A266	SKCM	TCGA	TRYQLDGLQ	DEG_APCC_DBOX_1	0.1667
p.R481C	DO37432	SKCM	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.1667
p.R481H	DO227745	COCA	ICGC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.1667
p.S464F	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.25
p.S464F	ACH-000840	Lung Cancer	CCLE	TRYQLDGLQ	DEG_APCC_DBOX_1	0.25
p.S464F	HCC-366	lung	COSMIC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.25
p.P457L	SIDM00476	Ovarian Carcinoma	GDSC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.0556
p.P457L	OV-17R	ovary	COSMIC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.0556
p.R468C	SIDM00140	Melanoma	GDSC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.8301
p.R468C	ACH-000968	Skin Cancer	CCLE	TRYQLDGLQ	DEG_APCC_DBOX_1	0.8301
p.R468C	COLO-792	skin	COSMIC	TRYQLDGLQ	DEG_APCC_DBOX_1	0.8301
p.D465G	ACH-000887	Brain Cancer	CCLE	TRYQLDGLQ	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02388	Collagen alpha-1	DEG_APCC_DBOX_1	467:475	TRYQLDGLQ	APC,CDC20,FZR1	0.6749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons