DegronMD

Uniprot ID: Q02388

Source protein: Collagen alpha-1

Source gene: COL7A1

Class: DEG_COP1_1

Location: 952:960

E3 ligase: COP1

DEGRON score: 0.9684

ASA_SCORE: 71.3889

COIL: 0.7199

CONS_SCORE: 0.5213

DSS_SCORE: 0.4164

HELIX: 0.0114

FCONS_SCORE: 1.0172

RIG_SCORE: 0.7445

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D970N	TCGA-FI-A2D5	UCEC	TCGA	TESPRVPSI	DEG_COP1_1	0.0556
p.D970N	DO41331	UCEC	ICGC	TESPRVPSI	DEG_COP1_1	0.0556
p.R963C	TCGA-GV-A6ZA	BLCA	TCGA	TESPRVPSI	DEG_COP1_1	0.25
p.R963C	DO49776	BLCA	ICGC	TESPRVPSI	DEG_COP1_1	0.25
p.R963C	SIDM00217	Colorectal Carcinoma	GDSC	TESPRVPSI	DEG_COP1_1	0.25
p.R963C	ACH-000999	Colon/Colorectal Cancer	CCLE	TESPRVPSI	DEG_COP1_1	0.25
p.R963C	SNU-1040	large_intestine	COSMIC	TESPRVPSI	DEG_COP1_1	0.25
p.S959R	TCGA-LN-A5U7	ESCA	TCGA	TESPRVPSI	DEG_COP1_1	0.7427
p.R951H	DO222501	COCA	ICGC	TESPRVPSI	DEG_COP1_1	0.3056
p.R951C	DO234393	ESAD	ICGC	TESPRVPSI	DEG_COP1_1	0.3056
p.R951C	DO233261	GACA	ICGC	TESPRVPSI	DEG_COP1_1	0.3056
p.T967N	DO228974	LICA	ICGC	TESPRVPSI	DEG_COP1_1	0.1389
p.P944T	DO229018	LICA	ICGC	TESPRVPSI	DEG_COP1_1	0.1111
p.R951S	DO229029	LICA	ICGC	TESPRVPSI	DEG_COP1_1	0.3056
p.R963S	DO229028	LICA	ICGC	TESPRVPSI	DEG_COP1_1	0.25
p.E953K	DO229275	THCA	ICGC	TESPRVPSI	DEG_COP1_1	0.591
p.A946T	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	TESPRVPSI	DEG_COP1_1	0.1667
p.A946T	ACH-000587	Lung Cancer	CCLE	TESPRVPSI	DEG_COP1_1	0.1667
p.A946T	NCI-H1975	lung	COSMIC	TESPRVPSI	DEG_COP1_1	0.1667
p.P958S	SIDM00781	Colorectal Carcinoma	GDSC	TESPRVPSI	DEG_COP1_1	0.6752
p.P958S	SIDM00780	Colorectal Carcinoma	GDSC	TESPRVPSI	DEG_COP1_1	0.6752
p.P958S	ACH-000967	Colon/Colorectal Cancer	CCLE	TESPRVPSI	DEG_COP1_1	0.6752
p.P958S	ACH-001199	Colon/Colorectal Cancer	CCLE	TESPRVPSI	DEG_COP1_1	0.6752
p.P958S	SNU-C2B	large_intestine	COSMIC	TESPRVPSI	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02388	Collagen alpha-1	DEG_COP1_1	952:960	TESPRVPSI	COP1	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons