DegronMD - Q86UZ6(ZBTB46)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S138L	TCGA-55-8089	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.S138L	DO23690	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.E145Q	TCGA-56-A4BW	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.E145Q	TCGA-UY-A9PE	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.E145Q	DO219043	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.E145Q	DO45441	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.V279I	TCGA-A5-A1OF	UCEC	TCGA	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.V279I	DO42256	UCEC	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.V279I	DO42568	UCEC	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.V279I	SIDM00968	Ovarian Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.V279I	SIDM01215	Ovarian Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.V279I	ACH-000542	Ovarian Cancer	CCLE	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.V279I	ACH-002140	Ovarian Cancer	CCLE	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.V279I	Hey	ovary	COSMIC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.V161M	TCGA-A6-3810	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.V161M	DO9434	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.V161M	DO46597	OV	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.T154M	TCGA-AA-3947	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.T154M	TCGA-CD-8524	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.T154M	DO8192	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.T154M	DO47787	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2778
p.D139Y	TCGA-AP-A059	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.D139Y	DO41361	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.S293T	TCGA-CM-6171	COAD	TCGA	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.6005
p.S293T	DO8151	COAD	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.6005
p.P295Q	TCGA-ED-A8O5	LIHC	TCGA	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.5924
p.P295Q	DO48558	LIHC	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.5924
p.P295S	TCGA-EE-A29S	SKCM	TCGA	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.5641
p.P295S	DO37936	SKCM	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.5641
p.P306S	TCGA-EE-A2GR	SKCM	TCGA	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1389
p.P306S	DO37996	SKCM	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1389
p.A148T	TCGA-EI-6510	READ	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7139
p.A148T	DO46523	OV	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7139
p.A148T	DO36387	READ	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7139
p.A148T	ACH-001461	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7139
p.H281Y	TCGA-EY-A2OP	UCEC	TCGA	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1389
p.H281Y	DO42560	UCEC	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1389
p.R280W	TCGA-F4-6570	COAD	TCGA	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1111
p.R280W	DO222427	BTCA	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1111
p.R280W	DO10443	COAD	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1111
p.S152N	TCGA-IE-A4EJ	SARC	TCGA	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7069
p.S152N	DO220155	SARC	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7069
p.A156T	DO233623	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.H281Q	DO228952	LICA	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1389
p.T283K	DO228974	LICA	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1944
p.S290R	DO228978	LICA	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.8538
p.P306Q	DO229042	LICA	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1389
p.E145K	DO231897	LINC	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.W305G	DO229446	SKCA	ICGC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.1667
p.G147D	DO38404	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.A160V	SIDM01175	Other Sarcomas	GDSC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.A160V	ACH-002309	Sarcoma	CCLE	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.A160V	SW684	soft tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.E145D	SIDM01064	Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.E145D	ACH-000267	Lymphoma	CCLE	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.E145D	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.S294F	SIDM00503	Gastric Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.7982
p.S294F	FU97	stomach	COSMIC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.7982
p.R291W	SIDM00839	Colorectal Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.7523
p.R291W	ACH-000950	Colon/Colorectal Cancer	CCLE	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.7523
p.P297L	SIDM00980	Gastric Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.7582
p.P297L	ACH-000948	Gastric Cancer	CCLE	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.7582
p.P297L	23132-87	stomach	COSMIC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation altering degron motif	0.7582
p.S308I	SIDM01577	Plasma Cell Myeloma	GDSC	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.S308I	ACH-000889	Myeloma	CCLE	DDSRASSPVPSF	DEG_COP1_1	288:299	Mutation rewiring degron network	0.0833
p.G147S	ACH-000903	Thyroid Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB46

UniProt ID: Q86UZ6

Entrez ID: 140685

Protein name: Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB46 in