DegronMD

Uniprot ID: Q86UZ6

Source protein: Zinc finger and BTB domain-containing protein 46

Source gene: ZBTB46

Class: DEG_COP1_1

Location: 288:299

E3 ligase: COP1

DEGRON score: 0.9971

ASA_SCORE: 81.6417

COIL: 0.8767

CONS_SCORE: 0.5661

DSS_SCORE: 0.5897

HELIX: 0.0863

FCONS_SCORE: 1.0683

RIG_SCORE: 0.6517

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V279I	TCGA-A5-A1OF	UCEC	TCGA	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.V279I	DO42256	UCEC	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.V279I	DO42568	UCEC	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.V279I	SIDM00968	Ovarian Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.V279I	SIDM01215	Ovarian Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.V279I	ACH-000542	Ovarian Cancer	CCLE	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.V279I	ACH-002140	Ovarian Cancer	CCLE	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.V279I	Hey	ovary	COSMIC	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.S293T	TCGA-CM-6171	COAD	TCGA	DDSRASSPVPSF	DEG_COP1_1	0.6005
p.S293T	DO8151	COAD	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.6005
p.P295Q	TCGA-ED-A8O5	LIHC	TCGA	DDSRASSPVPSF	DEG_COP1_1	0.5924
p.P295Q	DO48558	LIHC	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.5924
p.P295S	TCGA-EE-A29S	SKCM	TCGA	DDSRASSPVPSF	DEG_COP1_1	0.5641
p.P295S	DO37936	SKCM	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.5641
p.P306S	TCGA-EE-A2GR	SKCM	TCGA	DDSRASSPVPSF	DEG_COP1_1	0.1389
p.P306S	DO37996	SKCM	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.1389
p.H281Y	TCGA-EY-A2OP	UCEC	TCGA	DDSRASSPVPSF	DEG_COP1_1	0.1389
p.H281Y	DO42560	UCEC	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.1389
p.R280W	TCGA-F4-6570	COAD	TCGA	DDSRASSPVPSF	DEG_COP1_1	0.1111
p.R280W	DO222427	BTCA	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.1111
p.R280W	DO10443	COAD	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.1111
p.H281Q	DO228952	LICA	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.1389
p.T283K	DO228974	LICA	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.1944
p.S290R	DO228978	LICA	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.8538
p.P306Q	DO229042	LICA	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.1389
p.W305G	DO229446	SKCA	ICGC	DDSRASSPVPSF	DEG_COP1_1	0.1667
p.S294F	SIDM00503	Gastric Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	0.7982
p.S294F	FU97	stomach	COSMIC	DDSRASSPVPSF	DEG_COP1_1	0.7982
p.R291W	SIDM00839	Colorectal Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	0.7523
p.R291W	ACH-000950	Colon/Colorectal Cancer	CCLE	DDSRASSPVPSF	DEG_COP1_1	0.7523
p.P297L	SIDM00980	Gastric Carcinoma	GDSC	DDSRASSPVPSF	DEG_COP1_1	0.7582
p.P297L	ACH-000948	Gastric Cancer	CCLE	DDSRASSPVPSF	DEG_COP1_1	0.7582
p.P297L	23132-87	stomach	COSMIC	DDSRASSPVPSF	DEG_COP1_1	0.7582
p.S308I	SIDM01577	Plasma Cell Myeloma	GDSC	DDSRASSPVPSF	DEG_COP1_1	0.0833
p.S308I	ACH-000889	Myeloma	CCLE	DDSRASSPVPSF	DEG_COP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DDSRASSPVPSF

Degron related mutations and impact score

Drug responses associated with ZBTB46 mutations

All proteins holding degron of DDSRASSPVPSF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UZ6	Zinc finger and BTB domain-containing protein 46	DEG_COP1_1	288:299	DDSRASSPVPSF	COP1	0.9971	More...