DegronMD - Q5VTR2(RNF20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K689N	TCGA-AX-A05Z	UCEC	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation substituting flanking lysine	0.3333
p.K689N	TCGA-EO-A22U	UCEC	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation substituting flanking lysine	0.3333
p.K689N	DO40884	UCEC	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation substituting flanking lysine	0.3333
p.K689N	DO43755	UCEC	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation substituting flanking lysine	0.3333
p.D683N	TCGA-BR-8680	STAD	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.5821
p.D683N	DO47769	STAD	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.5821
p.A163T	TCGA-CM-6162	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation altering degron motif	0.7139
p.A163T	DO8479	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation altering degron motif	0.7139
p.A163T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation altering degron motif	0.7139
p.A163T	ACH-000980	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation altering degron motif	0.7139
p.A163T	NCI-H1155	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation altering degron motif	0.7139
p.K668N	TCGA-EO-A22U	UCEC	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation substituting flanking lysine	0.1944
p.K668N	DO43755	UCEC	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation substituting flanking lysine	0.1944
p.L677I	TCGA-ND-A4WC	UCS	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.6063
p.R177L	TCGA-NJ-A4YF	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.0556
p.R177L	DO218940	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.0556
p.E691D	DO229026	LICA	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.1667
p.A160T	DO231022	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.25
p.A155T	DO231183	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1111
p.F156V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1389
p.F156V	ACH-002222	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1389
p.F156V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1389
p.D676A	SIDM00118	Colorectal Carcinoma	GDSC	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.3056
p.D676A	ACH-001081	Colon/Colorectal Cancer	CCLE	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.3056
p.D676A	HCC2998	large intestine	COSMIC	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.3056
p.R680T	SIDM01503	Small Cell Lung Carcinoma	GDSC	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.6765
p.R680T	ACH-000844	Lung Cancer	CCLE	LRQRLKDLE	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.6765
p.R177H	SIDM01611	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.0556
p.R177H	ACH-000996	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.0556

Kaplan plot for RNF20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF20

UniProt ID: Q5VTR2

Entrez ID: 56254

Protein name: E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF20 in