DegronMD

Uniprot ID: Q5VTR2

Source protein: E3 ubiquitin-protein ligase BRE1A

Source gene: RNF20

Class: DEG_APCC_DBOX_1

Location: 677:685

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5126

ASA_SCORE: 101.5

COIL: 0.0129

CONS_SCORE: 0.4427

DSS_SCORE: 0.4873

HELIX: 0.9877

FCONS_SCORE: 1.1491

RIG_SCORE: 0.7479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K689N	TCGA-AX-A05Z	UCEC	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	0.3333
p.K689N	TCGA-EO-A22U	UCEC	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	0.3333
p.K689N	DO40884	UCEC	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	0.3333
p.K689N	DO43755	UCEC	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	0.3333
p.D683N	TCGA-BR-8680	STAD	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	0.5821
p.D683N	DO47769	STAD	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	0.5821
p.K668N	TCGA-EO-A22U	UCEC	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	0.1944
p.K668N	DO43755	UCEC	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	0.1944
p.L677I	TCGA-ND-A4WC	UCS	TCGA	LRQRLKDLE	DEG_APCC_DBOX_1	0.6063
p.E691D	DO229026	LICA	ICGC	LRQRLKDLE	DEG_APCC_DBOX_1	0.1667
p.D676A	SIDM00118	Colorectal Carcinoma	GDSC	LRQRLKDLE	DEG_APCC_DBOX_1	0.3056
p.D676A	ACH-001081	Colon/Colorectal Cancer	CCLE	LRQRLKDLE	DEG_APCC_DBOX_1	0.3056
p.D676A	HCC2998	large_intestine	COSMIC	LRQRLKDLE	DEG_APCC_DBOX_1	0.3056
p.R680T	SIDM01503	Small Cell Lung Carcinoma	GDSC	LRQRLKDLE	DEG_APCC_DBOX_1	0.6765
p.R680T	ACH-000844	Lung Cancer	CCLE	LRQRLKDLE	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VTR2	E3 ubiquitin-protein ligase BRE1A	DEG_APCC_DBOX_1	677:685	LRQRLKDLE	APC,CDC20,FZR1	0.5126	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons