DegronMD - O43189(PHF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S492L	TCGA-78-7147	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.25
p.S497F	TCGA-AP-A0LM	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation altering degron motif	0.7982
p.S497F	DO43306	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation altering degron motif	0.7982
p.C327S	TCGA-CQ-5334	HNSC	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.643
p.C327S	DO16053	HNSC	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.643
p.P342S	TCGA-DD-AADS	LIHC	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0556
p.P342S	DO52247	LIHC	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0556
p.P342L	TCGA-EE-A3JA	SKCM	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0556
p.P342L	DO47625	SKCM	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0556
p.P486T	TCGA-EO-A3KX	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.0833
p.P486T	DO219774	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.0833
p.S501L	TCGA-S5-AA26	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2778
p.S501L	DO51904	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2778
p.I322T	TCGA-UF-A71D	HNSC	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.2778
p.I322T	DO52109	HNSC	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.2778
p.P338L	TCGA-W3-AA1V	SKCM	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.1667
p.P338L	DO51276	SKCM	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.1667
p.S504F	TCGA-XF-AAN0	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1944
p.S504F	DO51941	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1944
p.I317T	DO233700	GACA	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.1389
p.R334Q	DO233888	GACA	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.2778
p.P342A	SIDM00111	Glioma	GDSC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0556
p.P342A	U251	central nervous system	COSMIC	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0556
p.A489T	ACH-001063	Ovarian Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.E321Q	ACH-001864	Bile Duct Cancer	CCLE	KRKCLFGLH	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.25

Kaplan plot for PHF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF1

UniProt ID: O43189

Entrez ID: 5252

Protein name: PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF1 in