DegronMD

Uniprot ID: O43189

Source protein: PHD finger protein 1

Source gene: PHF1

Class: DEG_APCC_DBOX_1

Location: 324:332

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5643

ASA_SCORE: 48.7778

COIL: 0.2936

CONS_SCORE: 0.5617

DSS_SCORE: 0.4178

HELIX: 0.036

FCONS_SCORE: 1.0507

RIG_SCORE: 0.7764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C327S	TCGA-CQ-5334	HNSC	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	0.643
p.C327S	DO16053	HNSC	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	0.643
p.P342S	TCGA-DD-AADS	LIHC	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	0.0556
p.P342S	DO52247	LIHC	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	0.0556
p.P342L	TCGA-EE-A3JA	SKCM	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	0.0556
p.P342L	DO47625	SKCM	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	0.0556
p.I322T	TCGA-UF-A71D	HNSC	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	0.2778
p.I322T	DO52109	HNSC	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	0.2778
p.P338L	TCGA-W3-AA1V	SKCM	TCGA	KRKCLFGLH	DEG_APCC_DBOX_1	0.1667
p.P338L	DO51276	SKCM	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	0.1667
p.I317T	DO233700	GACA	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	0.1389
p.R334Q	DO233888	GACA	ICGC	KRKCLFGLH	DEG_APCC_DBOX_1	0.2778
p.P342A	SIDM00111	Glioma	GDSC	KRKCLFGLH	DEG_APCC_DBOX_1	0.0556
p.P342A	U251	central_nervous_system	COSMIC	KRKCLFGLH	DEG_APCC_DBOX_1	0.0556
p.E321Q	ACH-001864	Bile Duct Cancer	CCLE	KRKCLFGLH	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43189	PHD finger protein 1	DEG_APCC_DBOX_1	324:332	KRKCLFGLH	APC,CDC20,FZR1	0.5643	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons