DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
SERTAD4
UniProt ID:
Q9NUC0
Entrez ID:
56256
Protein name:
SERTA domain-containing protein 4
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
nucleus [GO:0005634]...
nucleus [GO:0005634]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
SERTAD4
M
T
L
V
L
S
M
N
R
F
C
E
P
I
V
S
E
G
A
A
E
I
A
G
Y
Q
T
L
W
E
A
D
S
Y
G
G
P
S
P
P
G
P
A
Q
A
P
L
Q
G
D
R
G
A
G
P
P
L
A
G
S
H
Y
R
G
I
S
N
P
I
T
T
S
K
I
T
Y
F
K
R
K
Y
V
E
E
E
D
F
H
P
P
L
S
S
C
S
H
K
T
I
S
I
F
E
E
R
A
H
I
L
Y
M
S
L
E
K
L
K
F
I
D
D
P
E
V
Y
L
R
R
S
V
L
I
N
N
L
M
K
R
I
H
G
E
I
I
M
Q
N
N
W
C
F
P
A
C
S
F
N
G
T
S
A
Q
E
W
F
M
A
Q
D
C
P
Y
R
K
R
P
R
M
A
K
E
E
C
E
K
F
H
A
C
C
F
Y
Q
E
C
G
G
H
Y
L
N
L
P
L
S
V
N
A
N
V
G
S
A
S
T
A
A
S
S
P
S
A
S
S
S
S
S
S
S
S
S
S
P
P
L
P
L
P
S
C
S
R
Q
V
D
F
D
V
G
S
A
S
I
Y
K
S
D
G
Q
I
P
A
N
E
I
F
V
T
N
V
R
S
L
G
V
Q
E
K
A
K
L
N
D
E
K
A
N
D
D
T
N
R
D
G
G
P
L
S
H
E
P
V
G
N
D
L
A
F
E
C
K
G
Q
F
Y
D
Y
F
E
T
G
Y
N
E
R
N
N
V
N
E
S
W
K
K
S
L
R
K
K
E
A
S
P
P
S
N
K
L
C
C
S
K
G
S
K
I
50
100
150
200
250
300
350
Residue number
0
1
2
3
4
5
6
7
8
9
10
11
Number of mutated samples
0
0.5
1
1.5
2
2.5
3
Phosphorylation sites
Control panel
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All datasets
TCGA
ICGC
COSMIC
CCLE
GDSC
Show Degron:
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Degron
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Phosphorylation
Legend: PTM sites
Phosphorylation
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.S225F
TCGA-GF-A6C9
SKCM
TCGA
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation altering degron motif
0.9093
p.S225F
DO51254
SKCM
ICGC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation altering degron motif
0.9093
p.A222S
DO228978
LICA
ICGC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation altering degron motif
0.7588
p.T71A
TCGA-06-5416
GBM
TCGA
PITTS
DEG_SPOP_SBC_1
68:72
Mutation altering degron motif
0.7139
p.T71A
DO10880
GBM
ICGC
PITTS
DEG_SPOP_SBC_1
68:72
Mutation altering degron motif
0.7139
p.A222T
DO220888
MELA
ICGC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation altering degron motif
0.7139
p.A222T
SIDM00210
Ovarian Carcinoma
GDSC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation altering degron motif
0.7139
p.A222T
SIDM00711
Squamous Cell Lung Carcinoma
GDSC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation altering degron motif
0.7139
p.A222T
SIDM00271
Gastric Carcinoma
GDSC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation altering degron motif
0.7139
p.A222T
SIDM01752
Pancreatic Carcinoma
GDSC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation altering degron motif
0.7139
p.T71I
TCGA-G3-A5SL
LIHC
TCGA
PITTS
DEG_SPOP_SBC_1
68:72
Mutation altering degron motif
0.7078
p.T71I
DO44978
LIHC
ICGC
PITTS
DEG_SPOP_SBC_1
68:72
Mutation altering degron motif
0.7078
p.P220S
TCGA-BF-A1Q0
SKCM
TCGA
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation rewiring degron network
0.2778
p.P220S
DO47374
SKCM
ICGC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation rewiring degron network
0.2778
p.P220F
DO222868
MELA
ICGC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation rewiring degron network
0.2778
p.S66P
SIDM00845
Burkitt's Lymphoma
GDSC
PITTS
DEG_SPOP_SBC_1
68:72
Mutation rewiring degron network
0.2778
p.S218F
TCGA-D3-A8GO
SKCM
TCGA
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation rewiring degron network
0.2222
p.S218F
DO51242
SKCM
ICGC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation rewiring degron network
0.2222
p.S230F
TCGA-MA-AA41
CESC
TCGA
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation rewiring degron network
0.2222
p.S230F
DO219723
CESC
ICGC
ASSSS
DEG_SPOP_SBC_1
222:226
Mutation rewiring degron network
0.2222
Showing 1 to 20 of 29 entries
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Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for SERTAD4 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc