DegronMD - Q9NUC0(SERTAD4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T71A	TCGA-06-5416	GBM	TCGA	PITTS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7139
p.T71A	DO10880	GBM	ICGC	PITTS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7139
p.P220S	TCGA-BF-A1Q0	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2778
p.P220S	DO47374	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2778
p.S218F	TCGA-D3-A8GO	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2222
p.S218F	DO51242	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2222
p.S232F	TCGA-EB-A24D	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1667
p.S232F	DO37440	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1667
p.S231F	TCGA-EK-A3GK	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1944
p.S231F	DO49964	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1944
p.T71I	TCGA-G3-A5SL	LIHC	TCGA	PITTS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7078
p.T71I	DO44978	LIHC	ICGC	PITTS	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7078
p.S225F	TCGA-GF-A6C9	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.9093
p.S225F	DO51254	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.9093
p.S230F	TCGA-MA-AA41	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2222
p.S230F	DO219723	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2222
p.R79S	DO228252	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1389
p.R79M	DO228976	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1389
p.A222S	DO228978	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7588
p.A58S	DO228985	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0556
p.A58S	DO229045	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0556
p.R63S	DO229026	LICA	ICGC	PITTS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1944
p.A222T	DO220888	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7139
p.A222T	SIDM00210	Ovarian Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7139
p.A222T	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7139
p.A222T	SIDM00271	Gastric Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7139
p.A222T	SIDM01752	Pancreatic Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7139
p.P220F	DO222868	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2778
p.S66P	SIDM00845	Burkitt's Lymphoma	GDSC	PITTS	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SERTAD4

UniProt ID: Q9NUC0

Entrez ID: 56256

Protein name: SERTA domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SERTAD4 in