DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DSGLSS
Uniprot ID:
Q9P227
Source protein:
Rho GTPase-activating protein 23
Source gene:
ARHGAP23
Class:
DEG_SCF_TRCP1_1
Location:
1444:1449
E3 ligase:
BTRC
DEGRON score:
0.9987
ASA_SCORE:
65.8667
COIL:
0.8155
CONS_SCORE:
0.2644
DSS_SCORE:
0.7088
HELIX:
0.144
FCONS_SCORE:
1.0388
RIG_SCORE:
0.578
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D1444E
ACH-000985
Colon/Colorectal Cancer
CCLE
DSGLSS
DEG_SCF_TRCP1_1
0.6758
p.A1455V
ACH-000996
Endometrial/Uterine Cancer
CCLE
DSGLSS
DEG_SCF_TRCP1_1
0.1667
Drug responses associated with ARHGAP23 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGLSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P227
Rho GTPase-activating protein 23
DEG_SCF_TRCP1_1
1444:1449
DSGLSS
BTRC
0.9987
More...