DegronMD

Uniprot ID: Q9P227

Source protein: Rho GTPase-activating protein 23

Source gene: ARHGAP23

Class: DEG_SIAH_1

Location: 366:374

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9986

ASA_SCORE: 61.2111

COIL: 0.6964

CONS_SCORE: 0.2896

DSS_SCORE: 0.4111

HELIX: 0.1377

FCONS_SCORE: 1.1025

RIG_SCORE: 0.7037

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G366V	TCGA-5P-A9K6	KIRP	TCGA	GPGALVSPR	DEG_SIAH_1	0.6421
p.A364T	TCGA-AA-3947	COAD	TCGA	GPGALVSPR	DEG_SIAH_1	0.2778
p.T359S	TCGA-CC-5264	LIHC	TCGA	GPGALVSPR	DEG_SIAH_1	0.1389
p.R374C	TCGA-EO-A22U	UCEC	TCGA	GPGALVSPR	DEG_SIAH_1	0.719
p.R374C	SIDM00121	T-Lymphoblastic Leukemia	GDSC	GPGALVSPR	DEG_SIAH_1	0.719
p.P377L	DO223732	CESC	ICGC	GPGALVSPR	DEG_SIAH_1	0.25
p.P377L	DO233203	GACA	ICGC	GPGALVSPR	DEG_SIAH_1	0.25
p.R373K	DO222572	MELA	ICGC	GPGALVSPR	DEG_SIAH_1	0.7237
p.A383T	DO42673	UCEC	ICGC	GPGALVSPR	DEG_SIAH_1	0.0833
p.C378R	SIDM01293	Colorectal Carcinoma	GDSC	GPGALVSPR	DEG_SIAH_1	0.2222
p.A381V	SIDM02015	Colorectal Carcinoma	GDSC	GPGALVSPR	DEG_SIAH_1	0.1389
p.A381V	ACH-002059	Leukemia	CCLE	GPGALVSPR	DEG_SIAH_1	0.1389
p.E363K	ACH-000894	Lung Cancer	CCLE	GPGALVSPR	DEG_SIAH_1	0.25
p.R384H	ACH-000939	Sarcoma	CCLE	GPGALVSPR	DEG_SIAH_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P227	Rho GTPase-activating protein 23	DEG_SIAH_1	366:374	GPGALVSPR	SIAH1,SIAH2,SIAH3	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons