DegronMD

Uniprot ID: Q9P227

Source protein: Rho GTPase-activating protein 23

Source gene: ARHGAP23

Class: DEG_SPOP_SBC_1

Location: 330:334

E3 ligase: SPOP

DEGRON score: 0.9921

ASA_SCORE: 64.2

COIL: 0.8422

CONS_SCORE: 0.2803

DSS_SCORE: 0.5399

HELIX: 0.113

FCONS_SCORE: 0.9974

RIG_SCORE: 0.7078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R327H	TCGA-FI-A2D0	UCEC	TCGA	PCSTS	DEG_SPOP_SBC_1	0.25
p.A337T	TCGA-UD-AAC6	MESO	TCGA	PCSTS	DEG_SPOP_SBC_1	0.25
p.R334H	DO225201	BRCA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.8244
p.R327C	DO227802	COCA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.25
p.R335Q	DO233942	GACA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.3056
p.L320H	DO228403	MALY	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.A341V	DO227676	PBCA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1389
p.G324S	DO41871	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15550	Lysine-specific demethylase 6A	DEG_SPOP_SBC_1	578:582	PCSTS	SPOP	0.9564	More...
P17813	Endoglin	DEG_SPOP_SBC_1	651:655	PCSTS	SPOP	0.9842	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1480:1484	PCSTS	SPOP	0.5597	More...
Q96QF0	Rab-3A-interacting protein	DEG_SPOP_SBC_1	108:112	PCSTS	SPOP	0.9786	More...
Q9C0D0	Phosphatase and actin regulator 1	DEG_SPOP_SBC_1	335:339	PCSTS	SPOP	0.9483	More...
Q9P227	Rho GTPase-activating protein 23	DEG_SPOP_SBC_1	330:334	PCSTS	SPOP	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons