DegronMD

Uniprot ID: Q96QF0

Source protein: Rab-3A-interacting protein

Source gene: RAB3IP

Class: DEG_SPOP_SBC_1

Location: 108:112

E3 ligase: SPOP

DEGRON score: 0.9786

ASA_SCORE: 78.36

COIL: 0.913

CONS_SCORE: 0.3018

DSS_SCORE: 0.3038

HELIX: 0.0512

FCONS_SCORE: 1.1498

RIG_SCORE: 0.6827

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G117R	TCGA-91-7771	LUAD	TCGA	PCSTS	DEG_SPOP_SBC_1	0.1944
p.D105Y	TCGA-94-A4VJ	LUSC	TCGA	PCSTS	DEG_SPOP_SBC_1	0.25
p.T111A	TCGA-GU-A42P	BLCA	TCGA	PCSTS	DEG_SPOP_SBC_1	0.7139
p.D105H	TCGA-NK-A5CT	LUSC	TCGA	PCSTS	DEG_SPOP_SBC_1	0.25
p.K100I	DO219087	BLCA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1111
p.S111C	DO52478	COCA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.7541
p.I110T	DO10880	GBM	ICGC	PCSTS	DEG_SPOP_SBC_1	0.7078
p.Y108S	DO15743	HNSC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.712
p.V98F	DO229028	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.C122F	DO229032	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.A122T	DO229050	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.R115K	DO229059	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.6944
p.R98K	DO44887	LIHC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.G101R	DO25807	LUAD	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1389
p.R117S	DO37707	SKCM	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1944
p.R98I	DO41752	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.R98I	DO43907	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.I99V	SIDM00473	Oral Cavity Carcinoma	GDSC	PCSTS	DEG_SPOP_SBC_1	0.0833
p.I99V	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.0833
p.V103G	SIDM00118	Colorectal Carcinoma	GDSC	PCSTS	DEG_SPOP_SBC_1	0.1944
p.V103G	HCC2998	large_intestine	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.1944
p.H102R	SIDM00164	Biliary Tract Carcinoma	GDSC	PCSTS	DEG_SPOP_SBC_1	0.1667
p.K109N	ACH-000593	Bladder Cancer	CCLE	PCSTS	DEG_SPOP_SBC_1	0.6918
p.Y108H	SNG-M	endometrium	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.7229
p.V121A	SK-MEL-2	skin	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.0833
p.K100T	RERF-LC-FM	lung	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.1111
p.K100T	HuP-T4	pancreas	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.1111
p.K100T	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.1111
p.K100T	KP-2	pancreas	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.1111
p.K100T	HSC-3	upper_aerodigestive_tract	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.1111
p.K100T	RERF-LC-KJ	lung	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.1111
p.K100T	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15550	Lysine-specific demethylase 6A	DEG_SPOP_SBC_1	578:582	PCSTS	SPOP	0.9564	More...
P17813	Endoglin	DEG_SPOP_SBC_1	651:655	PCSTS	SPOP	0.9842	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1480:1484	PCSTS	SPOP	0.5597	More...
Q96QF0	Rab-3A-interacting protein	DEG_SPOP_SBC_1	108:112	PCSTS	SPOP	0.9786	More...
Q9C0D0	Phosphatase and actin regulator 1	DEG_SPOP_SBC_1	335:339	PCSTS	SPOP	0.9483	More...
Q9P227	Rho GTPase-activating protein 23	DEG_SPOP_SBC_1	330:334	PCSTS	SPOP	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCSTS

Degron related mutations and impact score

Drug responses associated with RAB3IP mutations

All proteins holding degron of PCSTS