DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PCSTS
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
1480:1484
E3 ligase:
SPOP
DEGRON score:
0.5597
ASA_SCORE:
79.74
COIL:
0.8844
CONS_SCORE:
0.232
DSS_SCORE:
0.2541
HELIX:
0.0144
FCONS_SCORE:
1.0291
RIG_SCORE:
0.6816
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PCSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15550
Lysine-specific demethylase 6A
DEG_SPOP_SBC_1
578:582
PCSTS
SPOP
0.9564
More...
P17813
Endoglin
DEG_SPOP_SBC_1
651:655
PCSTS
SPOP
0.9842
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
1480:1484
PCSTS
SPOP
0.5597
More...
Q96QF0
Rab-3A-interacting protein
DEG_SPOP_SBC_1
108:112
PCSTS
SPOP
0.9786
More...
Q9C0D0
Phosphatase and actin regulator 1
DEG_SPOP_SBC_1
335:339
PCSTS
SPOP
0.9483
More...
Q9P227
Rho GTPase-activating protein 23
DEG_SPOP_SBC_1
330:334
PCSTS
SPOP
0.9921
More...