DegronMD

Uniprot ID: Q9C0D0

Source protein: Phosphatase and actin regulator 1

Source gene: PHACTR1

Class: DEG_SPOP_SBC_1

Location: 335:339

E3 ligase: SPOP

DEGRON score: 0.9483

ASA_SCORE: 66.24

COIL: 0.8346

CONS_SCORE: 0.3299

DSS_SCORE: 0.5692

HELIX: 0.0984

FCONS_SCORE: 0.8335

RIG_SCORE: 0.6473

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D349N	TCGA-AO-A03M	BRCA	TCGA	PCSTS	DEG_SPOP_SBC_1	0.0556
p.D349N	DO2216	BRCA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.R333W	TCGA-FI-A2D5	UCEC	TCGA	PCSTS	DEG_SPOP_SBC_1	0.2778
p.E328V	TCGA-UU-A93S	BRCA	TCGA	PCSTS	DEG_SPOP_SBC_1	0.1389
p.E328V	DO219645	BRCA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1389
p.N334S	DO219853	LGG	ICGC	PCSTS	DEG_SPOP_SBC_1	0.3056
p.E347D	DO229037	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1111
p.R349K	DO44670	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	0.0556
p.E347G	DO52402	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15550	Lysine-specific demethylase 6A	DEG_SPOP_SBC_1	578:582	PCSTS	SPOP	0.9564	More...
P17813	Endoglin	DEG_SPOP_SBC_1	651:655	PCSTS	SPOP	0.9842	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1480:1484	PCSTS	SPOP	0.5597	More...
Q96QF0	Rab-3A-interacting protein	DEG_SPOP_SBC_1	108:112	PCSTS	SPOP	0.9786	More...
Q9C0D0	Phosphatase and actin regulator 1	DEG_SPOP_SBC_1	335:339	PCSTS	SPOP	0.9483	More...
Q9P227	Rho GTPase-activating protein 23	DEG_SPOP_SBC_1	330:334	PCSTS	SPOP	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons