DegronMD - Q9C0D0(PHACTR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D349N	TCGA-AO-A03M	BRCA	TCGA	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0556
p.D349N	DO2216	BRCA	ICGC	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0556
p.E386K	TCGA-AP-A1E0	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1389
p.N375S	TCGA-B1-A654	KIRP	TCGA	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation altering degron motif	0.5958
p.E382K	TCGA-CV-7099	HNSC	TCGA	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.25
p.N375I	TCGA-EB-A4XL	SKCM	TCGA	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation altering degron motif	0.6169
p.D374A	TCGA-EO-A22R	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.3056
p.R333W	TCGA-FI-A2D5	UCEC	TCGA	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.E328V	TCGA-UU-A93S	BRCA	TCGA	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1389
p.E328V	DO219645	BRCA	ICGC	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1389
p.E382Q	DO1076	BRCA	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.25
p.E366K	DO2808	BRCA	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.0833
p.R376C	DO223732	CESC	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation altering degron motif	0.8301
p.P380S	DO50382	ESAD	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.3056
p.V383L	DO16622	KIRC	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.2222
p.E370Q	DO48495	KIRP	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1944
p.N334S	DO219853	LGG	ICGC	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.3056
p.D379Y	DO228948	LICA	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation altering degron motif	0.7325
p.E347D	DO229037	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1111
p.R349K	DO44670	LICA	ICGC	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0556
p.S378T	DO45492	LUSC	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation altering degron motif	0.7116
p.E367Q	DO221545	PACA	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1111
p.A384S	DO220011	SARC	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1944
p.R369Q	DO38887	STAD	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1667
p.D385G	DO38663	STAD	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1667
p.S378G	DO40924	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation altering degron motif	0.6993
p.R369W	DO43274	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1667
p.E347G	DO52402	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1111
p.V381A	DO41211	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.2778
p.E386D	SIDM00282	Colorectal Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1389
p.E386D	ACH-000998	Colon/Colorectal Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1389
p.E386D	CW-2	large intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.1389
p.S389Y	SIDM00534	Colorectal Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.0556
p.S389Y	ACH-000986	Colon/Colorectal Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.0556
p.S389Y	HT-115	large intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	375:379	Mutation rewiring degron network	0.0556

Kaplan plot for PHACTR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHACTR1

UniProt ID: Q9C0D0

Entrez ID: 221692

Protein name: Phosphatase and actin regulator 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHACTR1 in