DegronMD

Uniprot ID: Q9C0D0

Source protein: Phosphatase and actin regulator 1

Source gene: PHACTR1

Class: DEG_APCC_KENBOX_2

Location: 375:379

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7863

ASA_SCORE: 99.92

COIL: 0.8492

CONS_SCORE: 0.4729

DSS_SCORE: 0.587

HELIX: 0.0936

FCONS_SCORE: 1.1061

RIG_SCORE: 0.6644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E386K	TCGA-AP-A1E0	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	0.1389
p.N375S	TCGA-B1-A654	KIRP	TCGA	NKENV	DEG_APCC_KENBOX_2	0.5958
p.E382K	TCGA-CV-7099	HNSC	TCGA	NKENV	DEG_APCC_KENBOX_2	0.25
p.N375I	TCGA-EB-A4XL	SKCM	TCGA	NKENV	DEG_APCC_KENBOX_2	0.6169
p.D374A	TCGA-EO-A22R	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	0.3056
p.E382Q	DO1076	BRCA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.25
p.E366K	DO2808	BRCA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.0833
p.R376C	DO223732	CESC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.8301
p.P380S	DO50382	ESAD	ICGC	NKENV	DEG_APCC_KENBOX_2	0.3056
p.V383L	DO16622	KIRC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.2222
p.E370Q	DO48495	KIRP	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1944
p.D379Y	DO228948	LICA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.7325
p.S378T	DO45492	LUSC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.7116
p.E367Q	DO221545	PACA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1111
p.A384S	DO220011	SARC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1944
p.R369Q	DO38887	STAD	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1667
p.D385G	DO38663	STAD	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1667
p.S378G	DO40924	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.6993
p.R369W	DO43274	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1667
p.V381A	DO41211	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.2778
p.E386D	SIDM00282	Colorectal Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	0.1389
p.E386D	ACH-000998	Colon/Colorectal Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	0.1389
p.E386D	CW-2	large_intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.1389
p.S389Y	SIDM00534	Colorectal Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	0.0556
p.S389Y	ACH-000986	Colon/Colorectal Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	0.0556
p.S389Y	HT-115	large_intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14680	Maternal embryonic leucine zipper kinase	DEG_APCC_KENBOX_2	422:426	NKENV	APC,CDC20,FZR1	0.9994	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_APCC_KENBOX_2	137:141	NKENV	APC,CDC20,FZR1	0.7459	More...
Q9C0D0	Phosphatase and actin regulator 1	DEG_APCC_KENBOX_2	375:379	NKENV	APC,CDC20,FZR1	0.7863	More...
Q9HC77	Centromere protein J	DEG_APCC_KENBOX_2	499:503	NKENV	APC,CDC20,FZR1	0.8995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENV

Degron related mutations and impact score

Drug responses associated with PHACTR1 mutations

All proteins holding degron of NKENV