DegronMD

Uniprot ID: Q96EP1

Source protein: E3 ubiquitin-protein ligase CHFR

Source gene: CHFR

Class: DEG_APCC_KENBOX_2

Location: 137:141

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7459

ASA_SCORE: 83.24

COIL: 0.5006

CONS_SCORE: 0.3821

DSS_SCORE: 0.6077

HELIX: 0.2794

FCONS_SCORE: 1.0703

RIG_SCORE: 0.7056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G144E	TCGA-DX-A8BP	SARC	TCGA	NKENV	DEG_APCC_KENBOX_2	0.25
p.G144E	DO220056	SARC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.25
p.M129I	TCGA-UY-A9PA	BLCA	TCGA	NKENV	DEG_APCC_KENBOX_2	0.1111
p.M129I	DO219040	BLCA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1111
p.A144S	DO234285	ESAD	ICGC	NKENV	DEG_APCC_KENBOX_2	0.25
p.C139S	DO14236	HNSC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.7541
p.N137K	SIDM00072	Non-Cancerous	GDSC	NKENV	DEG_APCC_KENBOX_2	0.5806
p.N137K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	0.5806
p.N137K	SIDM00493	Other Solid Cancers	GDSC	NKENV	DEG_APCC_KENBOX_2	0.5806
p.N137K	SIDM00672	Hepatocellular Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	0.5806
p.A136S	SIDM00817	Kidney Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	0.3056
p.A136S	ACH-002191	Kidney Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	0.3056
p.A136S	RCC-JW	kidney	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.3056
p.A148S	ACH-000990	Endometrial/Uterine Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	0.1389
p.P128L	ACH-001550	Skin Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	0.0833
p.P128L	MCC13	skin	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.0833
p.P151Q	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14680	Maternal embryonic leucine zipper kinase	DEG_APCC_KENBOX_2	422:426	NKENV	APC,CDC20,FZR1	0.9994	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_APCC_KENBOX_2	137:141	NKENV	APC,CDC20,FZR1	0.7459	More...
Q9C0D0	Phosphatase and actin regulator 1	DEG_APCC_KENBOX_2	375:379	NKENV	APC,CDC20,FZR1	0.7863	More...
Q9HC77	Centromere protein J	DEG_APCC_KENBOX_2	499:503	NKENV	APC,CDC20,FZR1	0.8995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons