DegronMD - Q14680(MELK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A432V	TCGA-AG-A002	READ	TCGA	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.1667
p.K434N	TCGA-AX-A05Z	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation blocking ubiquitination signal	0.5556
p.E424D	TCGA-BR-8680	STAD	TCGA	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation altering degron motif	0.6758
p.T428A	TCGA-RB-A7B8	PAAD	TCGA	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation blocking phosphorylation signal	0.7222
p.P412L	DO51623	CESC	ICGC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.0556
p.K418T	DO9876	COAD	ICGC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.2222
p.K418N	DO48286	ESCA	ICGC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.2222
p.V416I	DO33232	PACA	ICGC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.1667
p.R431C	DO50284	SKCM	ICGC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation blocking phosphorylation signal	0.6389
p.P435H	DO47578	SKCM	ICGC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.0833
p.P435S	DO41752	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.0833
p.P415S	DO43755	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation blocking phosphorylation signal	0.5833
p.H429Y	CAMA-1	breast	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.25
p.P431S	CP67-MEL	skin	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation blocking phosphorylation signal	0.6389
p.I425K	EN	endometrium	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation altering degron motif	0.7531
p.T412M	SNU-1040	large intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.0556
p.L426F	OV-90	ovary	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation altering degron motif	0.6981
p.R431W	SNU-1040	large intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation blocking phosphorylation signal	0.6389
p.T419M	SNU-1040	large intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation substituting flanking lysine	0.3611
p.E415G	IGROV-1	ovary	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation blocking phosphorylation signal	0.5833
p.I416K	EN	endometrium	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.1667
p.E424G	IGROV-1	ovary	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation altering degron motif	0.7199
p.T428M	SNU-1040	large intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation blocking phosphorylation signal	0.7222
p.L417F	OV-90	ovary	COSMIC	NKENV	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.1944

Kaplan plot for MELK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MELK

UniProt ID: Q14680

Entrez ID: 9833

Protein name: Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MELK in