DegronMD

Uniprot ID: Q14680

Source protein: Maternal embryonic leucine zipper kinase

Source gene: MELK

Class: DEG_APCC_KENBOX_2

Location: 422:426

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9994

ASA_SCORE: 111.68

COIL: 0.8406

CONS_SCORE: 0.431

DSS_SCORE: 0.4799

HELIX: 0.1358

FCONS_SCORE: 1.0848

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A432V	TCGA-AG-A002	READ	TCGA	NKENV	DEG_APCC_KENBOX_2	0.1667
p.K434N	TCGA-AX-A05Z	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	0.5556
p.E424D	TCGA-BR-8680	STAD	TCGA	NKENV	DEG_APCC_KENBOX_2	0.6758
p.T428A	TCGA-RB-A7B8	PAAD	TCGA	NKENV	DEG_APCC_KENBOX_2	0.7222
p.P412L	DO51623	CESC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.0556
p.K418T	DO9876	COAD	ICGC	NKENV	DEG_APCC_KENBOX_2	0.2222
p.K418N	DO48286	ESCA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.2222
p.V416I	DO33232	PACA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1667
p.R431C	DO50284	SKCM	ICGC	NKENV	DEG_APCC_KENBOX_2	0.6389
p.P435H	DO47578	SKCM	ICGC	NKENV	DEG_APCC_KENBOX_2	0.0833
p.P435S	DO41752	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.0833
p.P415S	DO43755	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.5833
p.H429Y	CAMA-1	breast	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.25
p.P431S	CP67-MEL	skin	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.6389
p.I425K	EN	endometrium	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.7531
p.T412M	SNU-1040	large_intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.0556
p.L426F	OV-90	ovary	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.6981
p.R431W	SNU-1040	large_intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.6389
p.T419M	SNU-1040	large_intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.3611
p.E415G	IGROV-1	ovary	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.5833
p.I416K	EN	endometrium	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.1667
p.E424G	IGROV-1	ovary	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.7199
p.T428M	SNU-1040	large_intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.7222
p.L417F	OV-90	ovary	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14680	Maternal embryonic leucine zipper kinase	DEG_APCC_KENBOX_2	422:426	NKENV	APC,CDC20,FZR1	0.9994	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_APCC_KENBOX_2	137:141	NKENV	APC,CDC20,FZR1	0.7459	More...
Q9C0D0	Phosphatase and actin regulator 1	DEG_APCC_KENBOX_2	375:379	NKENV	APC,CDC20,FZR1	0.7863	More...
Q9HC77	Centromere protein J	DEG_APCC_KENBOX_2	499:503	NKENV	APC,CDC20,FZR1	0.8995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons