DegronMD

Uniprot ID: Q9HC77

Source protein: Centromere protein J

Source gene: CENPJ

Class: DEG_APCC_KENBOX_2

Location: 499:503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8995

ASA_SCORE: 108.96

COIL: 0.8094

CONS_SCORE: 0.3834

DSS_SCORE: 0.3706

HELIX: 0.1554

FCONS_SCORE: 1.2386

RIG_SCORE: 0.7121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S497P	TCGA-A5-A0G1	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	0.7222
p.S497P	DO42472	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.7222
p.G513D	TCGA-B5-A3FA	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	0.0556
p.G513D	DO52402	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	0.0556
p.D511Y	TCGA-IB-7644	PAAD	TCGA	NKENV	DEG_APCC_KENBOX_2	0.1111
p.D511Y	DO46671	PAAD	ICGC	NKENV	DEG_APCC_KENBOX_2	0.1111
p.E505D	DO224973	BRCA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.2778
p.E505D	DO52555	BRCA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.2778
p.S497Y	DO229015	LICA	ICGC	NKENV	DEG_APCC_KENBOX_2	0.7222
p.K494N	SIDM00217	Colorectal Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	0.3056
p.K494N	ACH-000999	Colon/Colorectal Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	0.3056
p.K494N	SNU-1040	large_intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	0.3056
p.T512A	ACH-001786	Colon/Colorectal Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14680	Maternal embryonic leucine zipper kinase	DEG_APCC_KENBOX_2	422:426	NKENV	APC,CDC20,FZR1	0.9994	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_APCC_KENBOX_2	137:141	NKENV	APC,CDC20,FZR1	0.7459	More...
Q9C0D0	Phosphatase and actin regulator 1	DEG_APCC_KENBOX_2	375:379	NKENV	APC,CDC20,FZR1	0.7863	More...
Q9HC77	Centromere protein J	DEG_APCC_KENBOX_2	499:503	NKENV	APC,CDC20,FZR1	0.8995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons