DegronMD - Q9HC77(CENPJ)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1127S	TCGA-17-Z025	LUAD	TCGA	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation altering degron motif	0.7427
p.S497P	TCGA-A5-A0G1	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation blocking phosphorylation signal	0.7222
p.S497P	DO42472	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation blocking phosphorylation signal	0.7222
p.G513D	TCGA-B5-A3FA	UCEC	TCGA	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation rewiring degron network	0.0556
p.G513D	DO52402	UCEC	ICGC	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation rewiring degron network	0.0556
p.P1126S	TCGA-EE-A3J4	SKCM	TCGA	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation altering degron motif	0.5641
p.P1126S	DO48604	SKCM	ICGC	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation altering degron motif	0.5641
p.D511Y	TCGA-IB-7644	PAAD	TCGA	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation rewiring degron network	0.1111
p.D511Y	DO46671	PAAD	ICGC	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation rewiring degron network	0.1111
p.E505D	DO224973	BRCA	ICGC	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation rewiring degron network	0.2778
p.E505D	DO52555	BRCA	ICGC	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation rewiring degron network	0.2778
p.S497Y	DO229015	LICA	ICGC	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation blocking phosphorylation signal	0.7222
p.L1133M	DO229027	LICA	ICGC	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation altering degron motif	0.5999
p.P1126L	DO222880	MELA	ICGC	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation altering degron motif	0.6471
p.P1138S	SIDM00545	Melanoma	GDSC	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation rewiring degron network	0.2222
p.P1138S	ACH-000987	Skin Cancer	CCLE	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation rewiring degron network	0.2222
p.P1138S	Mewo	skin	COSMIC	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation rewiring degron network	0.2222
p.L1130I	SIDM00217	Colorectal Carcinoma	GDSC	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation altering degron motif	0.7174
p.L1130I	ACH-000999	Colon/Colorectal Cancer	CCLE	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation altering degron motif	0.7174
p.L1130I	SNU-1040	large intestine	COSMIC	PREPLEPLN	DEG_APCC_DBOX_1	1126:1134	Mutation altering degron motif	0.7174
p.K494N	SIDM00217	Colorectal Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation substituting flanking lysine	0.3056
p.K494N	ACH-000999	Colon/Colorectal Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation substituting flanking lysine	0.3056
p.K494N	SNU-1040	large intestine	COSMIC	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation substituting flanking lysine	0.3056
p.T512A	ACH-001786	Colon/Colorectal Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	499:503	Mutation rewiring degron network	0.0833

Kaplan plot for CENPJ in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CENPJ

UniProt ID: Q9HC77

Entrez ID: 55835

Protein name: Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CENPJ in