DegronMD

Uniprot ID: Q9HC77

Source protein: Centromere protein J

Source gene: CENPJ

Class: DEG_APCC_DBOX_1

Location: 1126:1134

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5515

ASA_SCORE: 98.5778

COIL: 0.8973

CONS_SCORE: 0.3069

DSS_SCORE: 0.8026

HELIX: 0.0458

FCONS_SCORE: 1.0205

RIG_SCORE: 0.6112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1127S	TCGA-17-Z025	LUAD	TCGA	PREPLEPLN	DEG_APCC_DBOX_1	0.7427
p.P1126S	TCGA-EE-A3J4	SKCM	TCGA	PREPLEPLN	DEG_APCC_DBOX_1	0.5641
p.P1126S	DO48604	SKCM	ICGC	PREPLEPLN	DEG_APCC_DBOX_1	0.5641
p.L1133M	DO229027	LICA	ICGC	PREPLEPLN	DEG_APCC_DBOX_1	0.5999
p.P1126L	DO222880	MELA	ICGC	PREPLEPLN	DEG_APCC_DBOX_1	0.6471
p.P1138S	SIDM00545	Melanoma	GDSC	PREPLEPLN	DEG_APCC_DBOX_1	0.2222
p.P1138S	ACH-000987	Skin Cancer	CCLE	PREPLEPLN	DEG_APCC_DBOX_1	0.2222
p.P1138S	Mewo	skin	COSMIC	PREPLEPLN	DEG_APCC_DBOX_1	0.2222
p.L1130I	SIDM00217	Colorectal Carcinoma	GDSC	PREPLEPLN	DEG_APCC_DBOX_1	0.7174
p.L1130I	ACH-000999	Colon/Colorectal Cancer	CCLE	PREPLEPLN	DEG_APCC_DBOX_1	0.7174
p.L1130I	SNU-1040	large_intestine	COSMIC	PREPLEPLN	DEG_APCC_DBOX_1	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC77	Centromere protein J	DEG_APCC_DBOX_1	1126:1134	PREPLEPLN	APC,CDC20,FZR1	0.5515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons