DegronMD - Q96EP1(CHFR)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S178L	TCGA-AP-A1DK	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6556
p.S178L	DO42033	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6556
p.P177S	TCGA-D1-A167	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6752
p.P177S	DO40978	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6752
p.T468M	TCGA-D1-A17D	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2222
p.T468M	DO232761	PBCA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2222
p.T468M	DO41746	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2222
p.E173K	TCGA-D8-A27G	BRCA	TCGA	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2222
p.E173K	DO5465	BRCA	ICGC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2222
p.G144E	TCGA-DX-A8BP	SARC	TCGA	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.25
p.G144E	DO220056	SARC	ICGC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.25
p.A167T	TCGA-FI-A2D5	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.A167T	DO41331	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.S191F	TCGA-IR-A3LH	CESC	TCGA	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.S191F	DO44381	CESC	ICGC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.S464F	TCGA-K4-A54R	BLCA	TCGA	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7982
p.S464F	DO48611	BLCA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7982
p.M129I	TCGA-UY-A9PA	BLCA	TCGA	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.1111
p.M129I	DO219040	BLCA	ICGC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.1111
p.E450K	DO8858	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0556
p.T463M	DO227646	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7423
p.T463M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7423
p.T463M	ACH-000966	Ovarian Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7423
p.Y474H	DO234336	ESAD	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0556
p.A144S	DO234285	ESAD	ICGC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.25
p.Q472R	DO233871	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1111
p.C139S	DO14236	HNSC	ICGC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation altering degron motif	0.7541
p.P461T	DO228948	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.5919
p.L467M	DO228974	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.25
p.A460E	DO229028	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7701
p.Q472K	DO229038	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1111
p.S466C	DO229234	THCA	ICGC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2778
p.N137K	SIDM00072	Non-Cancerous	GDSC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation altering degron motif	0.5806
p.N137K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation altering degron motif	0.5806
p.N137K	SIDM00493	Other Solid Cancers	GDSC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation altering degron motif	0.5806
p.N137K	SIDM00672	Hepatocellular Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation altering degron motif	0.5806
p.V465I	SIDM01171	Glioblastoma	GDSC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.3056
p.P177L	SIDM00231	Kidney Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.7582
p.P177L	ACH-002167	Kidney Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.7582
p.P177L	NCC010	kidney	COSMIC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.7582
p.A136S	SIDM00817	Kidney Carcinoma	GDSC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.3056
p.A136S	ACH-002191	Kidney Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.3056
p.A136S	RCC-JW	kidney	COSMIC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.3056
p.E173Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2222
p.E173Q	H513	pleura	COSMIC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2222
p.D473Y	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0833
p.D473Y	TE-4	oesophagus	COSMIC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0833
p.P185L	ACH-000860	Lung Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2222
p.P185L	NCI-H358	lung	COSMIC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2222
p.R186C	ACH-000963	Colon/Colorectal Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1944
p.R186C	CCK-81	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1944
p.A148S	ACH-000990	Endometrial/Uterine Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.1389
p.P128L	ACH-001550	Skin Cancer	CCLE	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.0833
p.P128L	MCC13	skin	COSMIC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.0833
p.R463C	SNU-175	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.8301
p.P450L	WM-115	skin	COSMIC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0556
p.A183T	MCC26	skin	COSMIC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2778
p.D461Y	TE-4	oesophagus	COSMIC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7325
p.P179L	MCC13	skin	COSMIC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.7582
p.D453G	639-V	urinary tract	COSMIC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1389
p.P151Q	ATN-1	haematopoietic and lymphoid tissue	COSMIC	NKENV	DEG_APCC_KENBOX_2	137:141	Mutation rewiring degron network	0.0556
p.D171E	SKN	soft tissue	COSMIC	PSTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1667
p.E459G	AN3-CA	endometrium	COSMIC	APSTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.3056

Kaplan plot for CHFR in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHFR

UniProt ID: Q96EP1

Entrez ID: 55743

Protein name: E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CHFR in