DegronMD

Uniprot ID: Q96EP1

Source protein: E3 ubiquitin-protein ligase CHFR

Source gene: CHFR

Class: DEG_SPOP_SBC_1

Location: 460:464

E3 ligase: SPOP

DEGRON score: 0.8719

ASA_SCORE: 57.88

COIL: 0.793

CONS_SCORE: 0.3854

DSS_SCORE: 0.5206

HELIX: 0.0856

FCONS_SCORE: 1.0465

RIG_SCORE: 0.6496

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T468M	TCGA-D1-A17D	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	0.2222
p.T468M	DO232761	PBCA	ICGC	APSTS	DEG_SPOP_SBC_1	0.2222
p.T468M	DO41746	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	0.2222
p.S464F	TCGA-K4-A54R	BLCA	TCGA	APSTS	DEG_SPOP_SBC_1	0.7982
p.S464F	DO48611	BLCA	ICGC	APSTS	DEG_SPOP_SBC_1	0.7982
p.E450K	DO8858	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	0.0556
p.T463M	DO227646	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	0.7423
p.T463M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	0.7423
p.T463M	ACH-000966	Ovarian Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	0.7423
p.Y474H	DO234336	ESAD	ICGC	APSTS	DEG_SPOP_SBC_1	0.0556
p.Q472R	DO233871	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	0.1111
p.P461T	DO228948	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	0.5919
p.L467M	DO228974	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	0.25
p.A460E	DO229028	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	0.7701
p.Q472K	DO229038	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	0.1111
p.S466C	DO229234	THCA	ICGC	APSTS	DEG_SPOP_SBC_1	0.2778
p.V465I	SIDM01171	Glioblastoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.3056
p.D473Y	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	0.0833
p.D473Y	TE-4	oesophagus	COSMIC	APSTS	DEG_SPOP_SBC_1	0.0833
p.R463C	SNU-175	large_intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	0.8301
p.P450L	WM-115	skin	COSMIC	APSTS	DEG_SPOP_SBC_1	0.0556
p.D461Y	TE-4	oesophagus	COSMIC	APSTS	DEG_SPOP_SBC_1	0.7325
p.D453G	639-V	urinary_tract	COSMIC	APSTS	DEG_SPOP_SBC_1	0.1389
p.E459G	AN3-CA	endometrium	COSMIC	APSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	DEG_SPOP_SBC_1	2270:2274	APSTS	SPOP	0.9988	More...
O60721	Sodium/potassium/calcium exchanger 1	DEG_SPOP_SBC_1	374:378	APSTS	SPOP	0.895	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	760:764	APSTS	SPOP	0.9536	More...
O75962	Triple functional domain protein	DEG_SPOP_SBC_1	2330:2334	APSTS	SPOP	0.9832	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	282:286	APSTS	SPOP	0.9986	More...
P20333	Tumor necrosis factor receptor superfamily member 1B	DEG_SPOP_SBC_1	236:240	APSTS	SPOP	0.8766	More...
P23193	Transcription elongation factor A protein 1	DEG_SPOP_SBC_1	133:137	APSTS	SPOP	0.9964	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	26:30	APSTS	SPOP	0.9904	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	962:966	APSTS	SPOP	0.9991	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	762:766	APSTS	SPOP	0.8531	More...
Q14123	Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	DEG_SPOP_SBC_1	641:645	APSTS	SPOP	0.9831	More...
Q15007	Pre-mRNA-splicing regulator WTAP	DEG_SPOP_SBC_1	248:252	APSTS	SPOP	0.9316	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	108:112	APSTS	SPOP	0.9976	More...
Q66K74	Microtubule-associated protein 1S	DEG_SPOP_SBC_1	565:569	APSTS	SPOP	0.972	More...
Q6IQ49	Replication stress response regulator SDE2	DEG_SPOP_SBC_1	238:242	APSTS	SPOP	0.999	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2700:2704	APSTS	SPOP	0.9449	More...
Q86V42	Protein FAM124A	DEG_SPOP_SBC_1	500:504	APSTS	SPOP	0.9876	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	374:378	APSTS	SPOP	0.9854	More...
Q8NCP5	Zinc finger and BTB domain-containing protein 44	DEG_SPOP_SBC_1	381:385	APSTS	SPOP	0.9707	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5164:5168	APSTS	SPOP	0.9867	More...
Q96EP1	E3 ubiquitin-protein ligase CHFR	DEG_SPOP_SBC_1	460:464	APSTS	SPOP	0.8719	More...
Q96MG7	Non-structural maintenance of chromosomes element 3 homolog	DEG_SPOP_SBC_1	47:51	APSTS	SPOP	0.9985	More...
Q96N64	PWWP domain-containing protein 2A	DEG_SPOP_SBC_1	613:617	APSTS	SPOP	0.9195	More...
Q96T37	RNA-binding protein 15	DEG_SPOP_SBC_1	753:757	APSTS	SPOP	0.9492	More...
Q9H1K4	Mitochondrial glutamate carrier 2	DEG_SPOP_SBC_1	146:150	APSTS	SPOP	0.6475	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	573:577	APSTS	SPOP	0.9899	More...
Q9H8N7	Zinc finger protein 395	DEG_SPOP_SBC_1	64:68	APSTS	SPOP	0.9883	More...
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	114:118	APSTS	SPOP	0.8965	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	1162:1166	APSTS	SPOP	0.9964	More...
P0C7U3	Probable palmitoyltransferase ZDHHC11B	DEG_SPOP_SBC_1	346:350	APSTS	SPOP	0.9986	More...
Q5FWE3	Proline-rich transmembrane protein 3	DEG_SPOP_SBC_1	411:415	APSTS	SPOP	0.9643	More...
Q8NCU7	C2 calcium-dependent domain-containing protein 4A	DEG_SPOP_SBC_1	226:230	APSTS	SPOP	0.999	More...
Q9BUT9	MAPK regulated corepressor interacting protein 2	DEG_SPOP_SBC_1	76:80	APSTS	SPOP	0.9973	More...
Q9H2Y9	Solute carrier organic anion transporter family member 5A1	DEG_SPOP_SBC_1	85:89	APSTS	SPOP	0.9092	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	1255:1259	APSTS	SPOP	0.9733	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	1255:1259	APSTS	SPOP	0.9531	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1842:1846	APSTS	SPOP	0.9477	More...
Q9H8U3	AN1-type zinc finger protein 3	DEG_SPOP_SBC_1	49:53	APSTS	SPOP	0.8073	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSTS

Degron related mutations and impact score

Drug responses associated with CHFR mutations

All proteins holding degron of APSTS