DegronMD - Q66K74(MAP1S)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R637H	TCGA-A6-3809	COAD	TCGA	PRTPSPE	DEG_SCF_FBW7_2	636:642	Mutation altering degron motif	0.7133
p.R637H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRTPSPE	DEG_SCF_FBW7_2	636:642	Mutation altering degron motif	0.7133
p.R637H	ACH-000980	Lung Cancer	CCLE	PRTPSPE	DEG_SCF_FBW7_2	636:642	Mutation altering degron motif	0.7133
p.P560L	TCGA-CQ-7071	HNSC	TCGA	APSTS	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.1944
p.A960T	TCGA-D1-A103	UCEC	TCGA	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.0556
p.A630T	TCGA-EA-A3HU	CESC	TCGA	PRTPSPE	DEG_SCF_FBW7_2	636:642	Mutation rewiring degron network	0.1667
p.A558V	TCGA-F4-6856	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.1389
p.G930E	TCGA-L5-A891	ESCA	TCGA	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation rewiring degron network	0.1111
p.G599C	TCGA-MN-A4N4	LUAD	TCGA	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation rewiring degron network	0.1667
p.Q957R	DO1269	BRCA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.1389
p.A604T	DO6320	CESC	ICGC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation rewiring degron network	0.3056
p.A604T	DO227996	COCA	ICGC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation rewiring degron network	0.3056
p.R611H	DO8722	COAD	ICGC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation altering degron motif	0.8244
p.R611H	DO9708	COAD	ICGC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation altering degron motif	0.8244
p.R611H	DO23308	LINC	ICGC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation altering degron motif	0.8244
p.T653M	DO222790	COCA	ICGC	ERLSLSPLR	DEG_APCC_DBOX_1	652:660	Mutation altering degron motif	0.7423
p.R944H	DO233695	GACA	ICGC	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation altering degron motif	0.8244
p.R944H	DO233695	GACA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation altering degron motif	0.8244
p.R944H	DO36717	READ	ICGC	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation altering degron motif	0.8244
p.R944H	DO36717	READ	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation altering degron motif	0.8244
p.R946L	DO14159	HNSC	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation altering degron motif	0.8428
p.R958L	DO229045	LICA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.1111
p.G573C	DO26250	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.2222
p.S556N	DO26427	LUSC	ICGC	APSTS	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.0833
p.P657L	DO222632	MELA	ICGC	ERLSLSPLR	DEG_APCC_DBOX_1	652:660	Mutation altering degron motif	0.7582
p.A934T	DO34977	PACA	ICGC	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation rewiring degron network	0.2222
p.A934T	DO34977	PACA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.0556
p.A934T	DO42312	UCEC	ICGC	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation rewiring degron network	0.2222
p.A934T	DO42312	UCEC	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.0556
p.R611C	DO49439	PACA	ICGC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation altering degron motif	0.8301
p.R946C	DO228138	PBCA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation altering degron motif	0.8301
p.P568R	DO35588	PBCA	ICGC	APSTS	DEG_SPOP_SBC_1	565:569	Mutation altering degron motif	0.7512
p.L948F	DO37819	SKCM	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation altering degron motif	0.6981
p.P685L	DO37432	SKCM	ICGC	VTTPTVT	DEG_SCF_FBW7_1	672:678	Mutation rewiring degron network	0.1389
p.S675C	DO47805	STAD	ICGC	VTTPTVT	DEG_SCF_FBW7_1	672:678	Mutation altering degron motif	0.7541
p.R958S	DO229257	THCA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.1111
p.P610T	DO229264	THCA	ICGC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation altering degron motif	0.7031
p.L672R	DO229275	THCA	ICGC	VTTPTVT	DEG_SCF_FBW7_1	672:678	Mutation altering degron motif	0.8428
p.V951I	DO40936	UCEC	ICGC	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation rewiring degron network	0.1667
p.V951I	DO40936	UCEC	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.3056
p.R660Q	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ERLSLSPLR	DEG_APCC_DBOX_1	652:660	Mutation altering degron motif	0.6218
p.R660Q	ACH-000920	Leukemia	CCLE	ERLSLSPLR	DEG_APCC_DBOX_1	652:660	Mutation altering degron motif	0.6218
p.P609L	SIDM00392	Melanoma	GDSC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation altering degron motif	0.7582
p.P609L	ACH-000810	Skin Cancer	CCLE	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation altering degron motif	0.7582
p.P943T	SIDM00697	Small Cell Lung Carcinoma	GDSC	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation altering degron motif	0.5919
p.P943T	ACH-000830	Lung Cancer	CCLE	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation altering degron motif	0.5919
p.A577T	SIDM00447	B-Lymphoblastic Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.1111
p.S571C	SIDM00589	Oral Cavity Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.2778
p.S571C	ACH-000778	Head and Neck Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	565:569	Mutation rewiring degron network	0.2778
p.R653W	SIDM01554	Mesothelioma	GDSC	ERLSLSPLR	DEG_APCC_DBOX_1	652:660	Mutation altering degron motif	0.8634
p.G619V	SIDM01387	Small Cell Lung Carcinoma	GDSC	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation rewiring degron network	0.1389
p.G619V	ACH-000921	Lung Cancer	CCLE	LVATPSLE	DEG_SCF_FBW7_2	605:612	Mutation rewiring degron network	0.1389
p.P647T	SIDM01451	Pancreatic Carcinoma	GDSC	ERLSLSPLR	DEG_APCC_DBOX_1	652:660	Mutation rewiring degron network	0.1944
p.P647T	SIDM01451	Pancreatic Carcinoma	GDSC	PRTPSPE	DEG_SCF_FBW7_2	636:642	Mutation rewiring degron network	0.1944
p.P647T	ACH-000933	Pancreatic Cancer	CCLE	ERLSLSPLR	DEG_APCC_DBOX_1	652:660	Mutation rewiring degron network	0.1944
p.P647T	ACH-000933	Pancreatic Cancer	CCLE	PRTPSPE	DEG_SCF_FBW7_2	636:642	Mutation rewiring degron network	0.1944
p.P946L	ACH-000295	Leukemia	CCLE	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation altering degron motif	0.6471
p.P955S	ACH-000614	Skin Cancer	CCLE	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation rewiring degron network	0.0556
p.P955S	ACH-000614	Skin Cancer	CCLE	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.1944
p.P955S	ACH-002461	Skin Cancer	CCLE	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation rewiring degron network	0.0556
p.P955S	ACH-002461	Skin Cancer	CCLE	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.1944
p.S931L	ACH-001210	Rhabdoid	CCLE	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation rewiring degron network	0.1389
p.A664V	ACH-001841	Bile Duct Cancer	CCLE	ERLSLSPLR	DEG_APCC_DBOX_1	652:660	Mutation rewiring degron network	0.2222
p.A664V	ACH-001841	Bile Duct Cancer	CCLE	VTTPTVT	DEG_SCF_FBW7_1	672:678	Mutation rewiring degron network	0.1111
p.Q955K	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VSATPPKS	DEG_SCF_FBW7_1	938:945	Mutation rewiring degron network	0.0556
p.Q955K	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	944:950	Mutation rewiring degron network	0.1944

Kaplan plot for MAP1S in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP1S

UniProt ID: Q66K74

Entrez ID: 55201

Protein name: Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP1S in