DegronMD

Uniprot ID: Q66K74

Source protein: Microtubule-associated protein 1S

Source gene: MAP1S

Class: DEG_SCF_FBW7_1

Location: 672:678

E3 ligase: FBXW7

DEGRON score: 0.954

ASA_SCORE: 97.2143

COIL: 0.9531

CONS_SCORE: 0.3741

DSS_SCORE: 0.7006

HELIX: 0.0126

FCONS_SCORE: 0.7334

RIG_SCORE: 0.6801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P685L	DO37432	SKCM	ICGC	VTTPTVT	DEG_SCF_FBW7_1	0.1389
p.S675C	DO47805	STAD	ICGC	VTTPTVT	DEG_SCF_FBW7_1	0.7541
p.L672R	DO229275	THCA	ICGC	VTTPTVT	DEG_SCF_FBW7_1	0.8428
p.A664V	ACH-001841	Bile Duct Cancer	CCLE	VTTPTVT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K74	Microtubule-associated protein 1S	DEG_SCF_FBW7_1	672:678	VTTPTVT	FBXW7	0.954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons