DegronMD

Uniprot ID: Q66K74

Source protein: Microtubule-associated protein 1S

Source gene: MAP1S

Class: DEG_SCF_FBW7_2

Location: 605:612

E3 ligase: FBXW7

DEGRON score: 0.7627

ASA_SCORE: 90.2

COIL: 0.8875

CONS_SCORE: 0.3839

DSS_SCORE: 0.4863

HELIX: 0.0488

FCONS_SCORE: 1.0781

RIG_SCORE: 0.7082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G599C	TCGA-MN-A4N4	LUAD	TCGA	LVATPSLE	DEG_SCF_FBW7_2	0.1667
p.A604T	DO6320	CESC	ICGC	LVATPSLE	DEG_SCF_FBW7_2	0.3056
p.A604T	DO227996	COCA	ICGC	LVATPSLE	DEG_SCF_FBW7_2	0.3056
p.R611H	DO8722	COAD	ICGC	LVATPSLE	DEG_SCF_FBW7_2	0.8244
p.R611H	DO9708	COAD	ICGC	LVATPSLE	DEG_SCF_FBW7_2	0.8244
p.R611H	DO23308	LINC	ICGC	LVATPSLE	DEG_SCF_FBW7_2	0.8244
p.R611C	DO49439	PACA	ICGC	LVATPSLE	DEG_SCF_FBW7_2	0.8301
p.P610T	DO229264	THCA	ICGC	LVATPSLE	DEG_SCF_FBW7_2	0.7031
p.P609L	SIDM00392	Melanoma	GDSC	LVATPSLE	DEG_SCF_FBW7_2	0.7582
p.P609L	ACH-000810	Skin Cancer	CCLE	LVATPSLE	DEG_SCF_FBW7_2	0.7582
p.G619V	SIDM01387	Small Cell Lung Carcinoma	GDSC	LVATPSLE	DEG_SCF_FBW7_2	0.1389
p.G619V	ACH-000921	Lung Cancer	CCLE	LVATPSLE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K74	Microtubule-associated protein 1S	DEG_SCF_FBW7_2	605:612	LVATPSLE	FBXW7	0.7627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons