DegronMD

Uniprot ID: Q66K74

Source protein: Microtubule-associated protein 1S

Source gene: MAP1S

Class: DEG_SCF_FBW7_1

Location: 938:945

E3 ligase: FBXW7

DEGRON score: 0.9913

ASA_SCORE: 88.7875

COIL: 0.951

CONS_SCORE: 0.3326

DSS_SCORE: 0.4759

HELIX: 0.0123

FCONS_SCORE: 0.6592

RIG_SCORE: 0.6071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G930E	TCGA-L5-A891	ESCA	TCGA	VSATPPKS	DEG_SCF_FBW7_1	0.1111
p.R944H	DO233695	GACA	ICGC	VSATPPKS	DEG_SCF_FBW7_1	0.8244
p.R944H	DO36717	READ	ICGC	VSATPPKS	DEG_SCF_FBW7_1	0.8244
p.A934T	DO34977	PACA	ICGC	VSATPPKS	DEG_SCF_FBW7_1	0.2222
p.A934T	DO42312	UCEC	ICGC	VSATPPKS	DEG_SCF_FBW7_1	0.2222
p.V951I	DO40936	UCEC	ICGC	VSATPPKS	DEG_SCF_FBW7_1	0.1667
p.P943T	SIDM00697	Small Cell Lung Carcinoma	GDSC	VSATPPKS	DEG_SCF_FBW7_1	0.5919
p.P943T	ACH-000830	Lung Cancer	CCLE	VSATPPKS	DEG_SCF_FBW7_1	0.5919
p.P955S	ACH-000614	Skin Cancer	CCLE	VSATPPKS	DEG_SCF_FBW7_1	0.0556
p.P955S	ACH-002461	Skin Cancer	CCLE	VSATPPKS	DEG_SCF_FBW7_1	0.0556
p.S931L	ACH-001210	Rhabdoid	CCLE	VSATPPKS	DEG_SCF_FBW7_1	0.1389
p.Q955K	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VSATPPKS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K74	Microtubule-associated protein 1S	DEG_SCF_FBW7_1	938:945	VSATPPKS	FBXW7	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons