DegronMD

Uniprot ID: Q66K74

Source protein: Microtubule-associated protein 1S

Source gene: MAP1S

Class: DEG_SCF_FBW7_2

Location: 636:642

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 109.1429

COIL: 0.9637

CONS_SCORE: 0.45

DSS_SCORE: 0.7615

HELIX: 0.0171

FCONS_SCORE: 1.4379

RIG_SCORE: 0.5146

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R637H	TCGA-A6-3809	COAD	TCGA	PRTPSPE	DEG_SCF_FBW7_2	0.7133
p.R637H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRTPSPE	DEG_SCF_FBW7_2	0.7133
p.R637H	ACH-000980	Lung Cancer	CCLE	PRTPSPE	DEG_SCF_FBW7_2	0.7133
p.A630T	TCGA-EA-A3HU	CESC	TCGA	PRTPSPE	DEG_SCF_FBW7_2	0.1667
p.P647T	SIDM01451	Pancreatic Carcinoma	GDSC	PRTPSPE	DEG_SCF_FBW7_2	0.1944
p.P647T	ACH-000933	Pancreatic Cancer	CCLE	PRTPSPE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K74	Microtubule-associated protein 1S	DEG_SCF_FBW7_2	636:642	PRTPSPE	FBXW7	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons