DegronMD

Uniprot ID: Q66K74

Source protein: Microtubule-associated protein 1S

Source gene: MAP1S

Class: DEG_APCC_DBOX_1

Location: 652:660

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.948

ASA_SCORE: 99.3889

COIL: 0.8412

CONS_SCORE: 0.3991

DSS_SCORE: 0.7718

HELIX: 0.079

FCONS_SCORE: 1.0572

RIG_SCORE: 0.5984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T653M	DO222790	COCA	ICGC	ERLSLSPLR	DEG_APCC_DBOX_1	0.7423
p.P657L	DO222632	MELA	ICGC	ERLSLSPLR	DEG_APCC_DBOX_1	0.7582
p.R660Q	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ERLSLSPLR	DEG_APCC_DBOX_1	0.6218
p.R660Q	ACH-000920	Leukemia	CCLE	ERLSLSPLR	DEG_APCC_DBOX_1	0.6218
p.R653W	SIDM01554	Mesothelioma	GDSC	ERLSLSPLR	DEG_APCC_DBOX_1	0.8634
p.P647T	SIDM01451	Pancreatic Carcinoma	GDSC	ERLSLSPLR	DEG_APCC_DBOX_1	0.1944
p.P647T	ACH-000933	Pancreatic Cancer	CCLE	ERLSLSPLR	DEG_APCC_DBOX_1	0.1944
p.A664V	ACH-001841	Bile Duct Cancer	CCLE	ERLSLSPLR	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K74	Microtubule-associated protein 1S	DEG_APCC_DBOX_1	652:660	ERLSLSPLR	APC,CDC20,FZR1	0.948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons