DegronMD

Uniprot ID: Q66K74

Source protein: Microtubule-associated protein 1S

Source gene: MAP1S

Class: LIG_APCC_ABBAyCdc20_2

Location: 944:950

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9313

ASA_SCORE: 67.5857

COIL: 0.6746

CONS_SCORE: 0.6458

DSS_SCORE: 0.3484

HELIX: 0.0239

FCONS_SCORE: 1.72

RIG_SCORE: 0.7548

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R946L	DO14159	HNSC	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.8428
p.R946C	DO228138	PBCA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R944H	DO233695	GACA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R944H	DO36717	READ	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.8244
p.L948F	DO37819	SKCM	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.6981
p.P946L	ACH-000295	Leukemia	CCLE	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.6471
p.V951I	DO40936	UCEC	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P955S	ACH-000614	Skin Cancer	CCLE	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P955S	ACH-002461	Skin Cancer	CCLE	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q955K	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q957R	DO1269	BRCA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R958L	DO229045	LICA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R958S	DO229257	THCA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A960T	TCGA-D1-A103	UCEC	TCGA	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A934T	DO34977	PACA	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A934T	DO42312	UCEC	ICGC	KSPVYLD	LIG_APCC_ABBAyCdc20_2	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K74	Microtubule-associated protein 1S	LIG_APCC_ABBAyCdc20_2	944:950	KSPVYLD	APC,CDC20,FZR1	0.9313	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons