DegronMD - Q9H8U3(ZFAND3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T77A	TCGA-BJ-A0YZ	THCA	TCGA	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation altering degron motif	0.6028
p.T77A	DO40461	THCA	ICGC	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation altering degron motif	0.6028
p.E62K	TCGA-D8-A1J9	BRCA	TCGA	APSTS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.E62K	DO2067	BRCA	ICGC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.S61F	TCGA-EE-A2MJ	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.S61F	DO38099	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.N54D	TCGA-MP-A4TA	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.3056
p.N54D	DO45314	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.3056
p.S72T	TCGA-VQ-AA64	STAD	TCGA	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation rewiring degron network	0.3056
p.S72T	DO222381	STAD	ICGC	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation rewiring degron network	0.3056
p.E88K	DO218176	BRCA	ICGC	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation rewiring degron network	0.0833
p.A49T	DO233270	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7139
p.A49T	SIDM00217	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7139
p.A49T	ACH-000999	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7139
p.A49T	SNU-1040	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7139
p.D46Y	DO228985	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.25
p.K42E	DO23234	LINC	ICGC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation substituting flanking lysine	0.25
p.I73V	SIDM00845	Burkitt's Lymphoma	GDSC	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation altering degron motif	0.5965
p.I73V	SIDM01519	Head and Neck Carcinoma	GDSC	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation altering degron motif	0.5965
p.I73V	ACH-000786	Lymphoma	CCLE	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation altering degron motif	0.5965
p.I73V	ACH-000992	Head and Neck Cancer	CCLE	ITTPTLS	DEG_SCF_FBW7_1	73:79	Mutation altering degron motif	0.5965
p.A49V	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.5825
p.A49V	ACH-000062	Lung Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.5825
p.A49V	RERF-LC-MS	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.5825
p.S53N	ACH-001688	Kidney Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFAND3

UniProt ID: Q9H8U3

Entrez ID: 60685

Protein name: AN1-type zinc finger protein 3 (Testis-expressed protein 27)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFAND3 in