DegronMD

Uniprot ID: Q9H8U3

Source protein: AN1-type zinc finger protein 3

Source gene: ZFAND3

Class: DEG_SCF_FBW7_1

Location: 73:79

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 82.2571

COIL: 0.9283

CONS_SCORE: 0.4801

DSS_SCORE: 0.7348

HELIX: 0.0251

FCONS_SCORE: 1.1687

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T77A	TCGA-BJ-A0YZ	THCA	TCGA	ITTPTLS	DEG_SCF_FBW7_1	0.6028
p.T77A	DO40461	THCA	ICGC	ITTPTLS	DEG_SCF_FBW7_1	0.6028
p.S72T	TCGA-VQ-AA64	STAD	TCGA	ITTPTLS	DEG_SCF_FBW7_1	0.3056
p.S72T	DO222381	STAD	ICGC	ITTPTLS	DEG_SCF_FBW7_1	0.3056
p.E88K	DO218176	BRCA	ICGC	ITTPTLS	DEG_SCF_FBW7_1	0.0833
p.I73V	SIDM00845	Burkitt's Lymphoma	GDSC	ITTPTLS	DEG_SCF_FBW7_1	0.5965
p.I73V	SIDM01519	Head and Neck Carcinoma	GDSC	ITTPTLS	DEG_SCF_FBW7_1	0.5965
p.I73V	ACH-000786	Lymphoma	CCLE	ITTPTLS	DEG_SCF_FBW7_1	0.5965
p.I73V	ACH-000992	Head and Neck Cancer	CCLE	ITTPTLS	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8U3	AN1-type zinc finger protein 3	DEG_SCF_FBW7_1	73:79	ITTPTLS	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons