DegronMD - P20333(TNFRSF1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T222P	TCGA-06-0126	GBM	TCGA	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation rewiring degron network	0.1389
p.T222P	DO11519	GBM	ICGC	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation rewiring degron network	0.1389
p.P237Q	TCGA-A5-A1OF	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.5924
p.P237Q	DO42568	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.5924
p.P324L	TCGA-B5-A0KB	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.6471
p.P324L	DO41097	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.6471
p.A213P	TCGA-CU-A0YN	BLCA	TCGA	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0556
p.A213P	DO488	BLCA	ICGC	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0556
p.G212W	TCGA-D3-A2JG	SKCM	TCGA	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.G212W	DO47613	SKCM	ICGC	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.G313C	TCGA-DK-A3IU	BLCA	TCGA	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0556
p.G313C	DO612	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0556
p.E315K	TCGA-DU-6392	LGG	TCGA	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.E315K	DO22237	LGG	ICGC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.S248I	TCGA-EO-A22R	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.1111
p.S248I	DO42713	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.1111
p.S327N	TCGA-EO-A22R	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7069
p.S327N	DO42713	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7069
p.T227M	TCGA-F4-6809	COAD	TCGA	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation rewiring degron network	0.2778
p.T227M	TCGA-F4-6809	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.0833
p.T227M	DO10164	COAD	ICGC	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation rewiring degron network	0.2778
p.T227M	DO10164	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.0833
p.S329G	TCGA-PG-A917	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2778
p.S329G	DO52424	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2778
p.M196R	DO230334	COCA	ICGC	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.M196R	DO229003	COCA	ICGC	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.M196R	DO229346	LAML	ICGC	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.M196R	DO230659	LAML	ICGC	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.M196R	DO228947	LICA	ICGC	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.M196R	DO230937	LUSC	ICGC	VCTST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.E232K	DO229505	LAML	ICGC	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation altering degron motif	0.591
p.A337S	DO229027	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0556
p.A236V	DO229051	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.5825
p.S334L	DO229404	PRAD	ICGC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1389
p.T222R	DO228450	PRAD	ICGC	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation rewiring degron network	0.1389
p.A323V	DO229211	THCA	ICGC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.5825
p.Q317P	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.Q317P	ACH-000914	Lymphoma	CCLE	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.Q317P	HT	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.S336T	SIDM01120	Other Solid Cancers	GDSC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0833
p.S336T	ACH-002174	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0833
p.S336T	NCI-H720	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0833
p.Q225K	SIDM00901	Endometrial Carcinoma	GDSC	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation rewiring degron network	0.2222
p.Q225K	ACH-000940	Endometrial/Uterine Cancer	CCLE	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation rewiring degron network	0.2222
p.Q225K	AN3-CA	endometrium	COSMIC	PTPEPS	DEG_SCF_FBW7_1	229:234	Mutation rewiring degron network	0.2222

Kaplan plot for TNFRSF1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNFRSF1B

UniProt ID: P20333

Entrez ID: 7133

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNFRSF1B in