DegronMD

Uniprot ID: P20333

Source protein: Tumor necrosis factor receptor superfamily member 1B

Source gene: TNFRSF1B

Class: DEG_SCF_FBW7_1

Location: 229:234

E3 ligase: FBXW7

DEGRON score: 0.5671

ASA_SCORE: 94.2667

COIL: 0.9503

CONS_SCORE: 0.323

DSS_SCORE: 0.8055

HELIX: 0.015

FCONS_SCORE: 1.0708

RIG_SCORE: 0.5451

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T222P	TCGA-06-0126	GBM	TCGA	PTPEPS	DEG_SCF_FBW7_1	0.1389
p.T222P	DO11519	GBM	ICGC	PTPEPS	DEG_SCF_FBW7_1	0.1389
p.T227M	TCGA-F4-6809	COAD	TCGA	PTPEPS	DEG_SCF_FBW7_1	0.2778
p.T227M	DO10164	COAD	ICGC	PTPEPS	DEG_SCF_FBW7_1	0.2778
p.E232K	DO229505	LAML	ICGC	PTPEPS	DEG_SCF_FBW7_1	0.591
p.T222R	DO228450	PRAD	ICGC	PTPEPS	DEG_SCF_FBW7_1	0.1389
p.Q225K	SIDM00901	Endometrial Carcinoma	GDSC	PTPEPS	DEG_SCF_FBW7_1	0.2222
p.Q225K	ACH-000940	Endometrial/Uterine Cancer	CCLE	PTPEPS	DEG_SCF_FBW7_1	0.2222
p.Q225K	AN3-CA	endometrium	COSMIC	PTPEPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20333	Tumor necrosis factor receptor superfamily member 1B	DEG_SCF_FBW7_1	229:234	PTPEPS	FBXW7	0.5671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons