DegronMD

Uniprot ID: P20333

Source protein: Tumor necrosis factor receptor superfamily member 1B

Source gene: TNFRSF1B

Class: DEG_SPOP_SBC_1

Location: 199:203

E3 ligase: SPOP

DEGRON score: 0.995

ASA_SCORE: 55.76

COIL: 0.744

CONS_SCORE: 0.5205

DSS_SCORE: 0.49

HELIX: 0.112

FCONS_SCORE: 1.284

RIG_SCORE: 0.7372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A213P	TCGA-CU-A0YN	BLCA	TCGA	VCTST	DEG_SPOP_SBC_1	0.0556
p.A213P	DO488	BLCA	ICGC	VCTST	DEG_SPOP_SBC_1	0.0556
p.G212W	TCGA-D3-A2JG	SKCM	TCGA	VCTST	DEG_SPOP_SBC_1	0.0833
p.G212W	DO47613	SKCM	ICGC	VCTST	DEG_SPOP_SBC_1	0.0833
p.M196R	DO230334	COCA	ICGC	VCTST	DEG_SPOP_SBC_1	0.25
p.M196R	DO229003	COCA	ICGC	VCTST	DEG_SPOP_SBC_1	0.25
p.M196R	DO229346	LAML	ICGC	VCTST	DEG_SPOP_SBC_1	0.25
p.M196R	DO230659	LAML	ICGC	VCTST	DEG_SPOP_SBC_1	0.25
p.M196R	DO228947	LICA	ICGC	VCTST	DEG_SPOP_SBC_1	0.25
p.M196R	DO230937	LUSC	ICGC	VCTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20333	Tumor necrosis factor receptor superfamily member 1B	DEG_SPOP_SBC_1	199:203	VCTST	SPOP	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons