DegronMD - A6NM11(LRRC37A2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L833I	TCGA-A5-A1OF	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.1944
p.L833I	DO42568	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.1944
p.S171F	TCGA-FI-A2D0	UCEC	TCGA	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation blocking phosphorylation signal	0.5833
p.S171F	DO43891	UCEC	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation blocking phosphorylation signal	0.5833
p.K1253N	TCGA-GN-A26A	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.2778
p.K1253N	DO37861	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.2778
p.R168C	TCGA-MA-AA3Z	CESC	TCGA	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.2222
p.R168C	DO219722	CESC	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.2222
p.N105S	TCGA-VV-A829	LGG	TCGA	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.3056
p.N105S	DO51847	LGG	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.3056
p.S1246F	TCGA-WE-AAA0	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.0833
p.S1246F	DO51294	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.0833
p.R1269T	DO218176	BRCA	ICGC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.0556
p.T167I	DO229218	THCA	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.25
p.T167I	DO229248	THCA	ICGC	QRWSLAEII	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.25
p.P1266S	SIDM01117	Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.1389
p.S1257P	SIDM00018	Acute Myeloid Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation altering degron motif	0.6752
p.S1257P	ACH-000498	Leukemia	CCLE	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation altering degron motif	0.6752
p.A1255V	SIDM00217	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation altering degron motif	0.5825
p.A1262V	ACH-000999	Colon/Colorectal Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC37A2

UniProt ID: A6NM11

Entrez ID: 474170

Protein name: Leucine-rich repeat-containing protein 37A2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC37A2 in