DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LVPFLD
Uniprot ID:
A6NM11
Source protein:
Leucine-rich repeat-containing protein 37A2
Source gene:
LRRC37A2
Class:
LIG_APCC_ABBA_1
Location:
106:111
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9916
ASA_SCORE:
84.2
COIL:
0.9133
CONS_SCORE:
0.4537
DSS_SCORE:
0.6808
HELIX:
0.043
FCONS_SCORE:
1.1606
RIG_SCORE:
0.7573
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N105S
TCGA-VV-A829
LGG
TCGA
LVPFLD
LIG_APCC_ABBA_1
0.3056
p.N105S
DO51847
LGG
ICGC
LVPFLD
LIG_APCC_ABBA_1
0.3056
Drug responses associated with LRRC37A2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LVPFLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NM11
Leucine-rich repeat-containing protein 37A2
LIG_APCC_ABBA_1
106:111
LVPFLD
APC,CDC20,FZR1
0.9916
More...
A6NMS7
Leucine-rich repeat-containing protein 37A
LIG_APCC_ABBA_1
106:111
LVPFLD
APC,CDC20,FZR1
0.9907
More...
O60309
Leucine-rich repeat-containing protein 37A3
LIG_APCC_ABBA_1
106:111
LVPFLD
APC,CDC20,FZR1
0.7588
More...