DegronMD - O60309(LRRC37A3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E101K	TCGA-06-5416	GBM	TCGA	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.1944
p.E101K	DO10880	GBM	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.1944
p.E101K	SW684	soft tissue	COSMIC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.1944
p.A97V	TCGA-2W-A8YY	CESC	TCGA	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.0833
p.A97V	DO223732	CESC	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.0833
p.A1264V	TCGA-35-5375	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.1944
p.G1254A	TCGA-66-2763	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.3056
p.K814T	TCGA-BS-A0UF	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	824:828	Mutation substituting flanking lysine	0.1667
p.K814T	DO41488	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	824:828	Mutation substituting flanking lysine	0.1667
p.A1264S	TCGA-EI-6884	READ	TCGA	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.1944
p.F1251L	TCGA-FI-A2D5	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.2222
p.L102V	DO569	BLCA	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.2222
p.T116M	DO9708	COAD	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.1944
p.N605Y	DO228924	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.0556
p.L108F	DO228945	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation altering degron motif	0.6981
p.P106S	DO228945	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation altering degron motif	0.6752
p.A613S	DO228946	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.2778
p.A613S	DO228950	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.2778
p.A613S	DO229030	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.2778
p.A613S	DO229057	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.2778
p.L117Q	DO228946	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.1667
p.L117Q	DO229057	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.1667
p.D99Y	DO229045	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.1389
p.V118A	DO229047	LICA	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.1389
p.P619Q	DO23540	LIRI	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation altering degron motif	0.7035
p.N607I	DO228633	PRAD	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.1111
p.R609I	DO36556	READ	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.1667
p.L611F	DO37406	SKCM	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.2222
p.K109N	DO219773	UCEC	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation altering degron motif	0.6918
p.T121I	DO42328	UCEC	ICGC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.0556
p.R617Q	DO41584	UCEC	ICGC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation altering degron motif	0.7329
p.E624D	SIDM01314	Colorectal Carcinoma	GDSC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.2778
p.A1264T	SIDM00136	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.1944
p.A1264T	HT-29	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.1944
p.Q1267H	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	1255:1259	Mutation rewiring degron network	0.1111
p.R115Q	COLO-824	breast	COSMIC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.2222
p.N108K	MCF7	breast	COSMIC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation altering degron motif	0.6918
p.A107V	MDA-MB-453	breast	COSMIC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation altering degron motif	0.6936
p.A623V	SNU-175	large intestine	COSMIC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.3056
p.G625E	H2595	pleura	COSMIC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.25
p.C632Y	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	LTITPEPT	DEG_SCF_FBW7_1	615:622	Mutation substituting flanking lysine	0.1667
p.A106V	PF-382	haematopoietic and lymphoid tissue	COSMIC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation altering degron motif	0.6936
p.E105K	MDA-MB-361	breast	COSMIC	LVPFLD	LIG_APCC_ABBA_1	106:111	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC37A3

UniProt ID: O60309

Entrez ID: 374819

Protein name: Leucine-rich repeat-containing protein 37A3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC37A3 in