DegronMD

Uniprot ID: O60309

Source protein: Leucine-rich repeat-containing protein 37A3

Source gene: LRRC37A3

Class: DEG_SCF_FBW7_1

Location: 615:622

E3 ligase: FBXW7

DEGRON score: 0.9004

ASA_SCORE: 92.75

COIL: 0.9584

CONS_SCORE: 0.6041

DSS_SCORE: 0.5952

HELIX: 0.0165

FCONS_SCORE: 0.964

RIG_SCORE: 0.7013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N605Y	DO228924	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.0556
p.A613S	DO228946	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.2778
p.A613S	DO228950	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.2778
p.A613S	DO229030	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.2778
p.A613S	DO229057	LICA	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.2778
p.P619Q	DO23540	LIRI	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.7035
p.N607I	DO228633	PRAD	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.1111
p.R609I	DO36556	READ	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.1667
p.L611F	DO37406	SKCM	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.2222
p.R617Q	DO41584	UCEC	ICGC	LTITPEPT	DEG_SCF_FBW7_1	0.7329
p.E624D	SIDM01314	Colorectal Carcinoma	GDSC	LTITPEPT	DEG_SCF_FBW7_1	0.2778
p.A623V	SNU-175	large_intestine	COSMIC	LTITPEPT	DEG_SCF_FBW7_1	0.3056
p.G625E	H2595	pleura	COSMIC	LTITPEPT	DEG_SCF_FBW7_1	0.25
p.C632Y	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	LTITPEPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SCF_FBW7_1	615:622	LTITPEPT	FBXW7	0.8835	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SCF_FBW7_1	615:622	LTITPEPT	FBXW7	0.8835	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SCF_FBW7_1	615:622	LTITPEPT	FBXW7	0.9004	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons